Searchable abstracts of presentations at key conferences in endocrinology

ea0012p4 | Bone | SFE2006

Audit on the efficacy of intravenous Pamidronate in the treatment of osteoporosis

Arefin AN , Orme SM

IntroductionOsteoporosis is a common disease characterised by a decrease in bone mass attributed to an imbalance between bone formation and resorption. Oral bisphosphonates have proven efficacy in increasing bone mineral density (BMD) and fracture reduction. Prior to the introduction of i.v. Ibandronate, patients who were unable to tolerate oral bisphosphonate were treated with i.v. Pamidronate (APD).AimTo as...

ea0011p772 | Thyroid | ECE2006

A case of delayed diagnosis of pituitary resistance to thyroid hormone (PRTH)

Nyunt A , Orme SM

Resistance to thyroid hormone is a dominantly inherited condition of impaired tissue responsiveness to the action of thyroid hormone. Thyroid hormone levels are elevated with failure to suppress TSH.The presentation is highly variable. In individuals with generalized resistance to thyroid hormone (GRTH) appear to have eumetabolic state with compensatory high thyroid hormone levels. In contrast, those who appear to have hyper metabolic features but may have similar thyroid horm...

ea0067o31 | Oral Presentations | EYES2019

Onset of radiation-induced hypopituitarism in pituitary adenomas

Seejore K , Tudawe G , Mansoor T , Lynch JM , Orme SM , Phillips N , Loughrey C , Murray RD

Objective: Radiotherapy (RT) can achieve tumour control rates of over 90% in pituitary adenomas. The commonest toxicity of irradiation is hypopituitarism. The exact incidence is variable and requires long-term testing for deficiency of all hypothalamic-pituitary axes (HPA). The aim of this study is to determine the time to onset of individual hormonal deficiencies and establish a timeframe for endocrine testing post-RT.Methods: We retrospectively assesse...

ea0050p294 | Neuroendocrinology and Pituitary | SFEBES2017

Outcomes of endoscopic, endo-nasal, trans-sphenoidal pituitary adenoma surgery for Acromegaly and Cushing’s disease: A single UK centre experience

Pearson SM , Alavi SA , Seejore K , Robins JMW , Tyagi A , Nix P , Wilson T , Phillips N , Orme SM , Murray RD

Background: Endoscopic trans-sphenoidal surgery is a technical advance for treatment of pituitary tumours. We present the outcomes of patients with Acromegaly or CushingÂ’s disease undergoing selective pituitary adenomectomy in a regional neurosurgical centre.Methods: Retrospective cohort study August 2010-August 2017. Imaging, histology and pituitary hormone assessments were collated pre and post-operatively to...

ea0050p294 | Neuroendocrinology and Pituitary | SFEBES2017

Outcomes of endoscopic, endo-nasal, trans-sphenoidal pituitary adenoma surgery for Acromegaly and Cushing’s disease: A single UK centre experience

Pearson SM , Alavi SA , Seejore K , Robins JMW , Tyagi A , Nix P , Wilson T , Phillips N , Orme SM , Murray RD

Background: Endoscopic trans-sphenoidal surgery is a technical advance for treatment of pituitary tumours. We present the outcomes of patients with Acromegaly or CushingÂ’s disease undergoing selective pituitary adenomectomy in a regional neurosurgical centre.Methods: Retrospective cohort study August 2010-August 2017. Imaging, histology and pituitary hormone assessments were collated pre and post-operatively to...