Searchable abstracts of presentations at key conferences in endocrinology

ea0013p107 | Clinical practice/governance and case reports | SFEBES2007

Double Y syndrome as a cause of gynaecomastia

Sharfi MO , Nussey SS , Bano G

A 68 year old retired accountant presented with loss of libido, reduced shaving frequency, obesity and gynaecomastia. His past medical history included osteoarthritis and facial acne. There was no related family history and he was taking no medications. He reported having two children.On examination the BMI was 31.7 kg/m2 and height 181 cm. He was normotensive and bilateral gynaecomastia was noted. He has reduced body hair; testicular volume w...

ea0008p78 | Reproduction | SFE2004

Androgens inhibit atresia and retard early development of ovarian follicles: a model for PCOS?

Qureshi AI , Bano G , Whitehead S , Nussey SS , Mason HD

BackgroundPCOS is the commonest endocrinopathy in women. PCO are typified by increased ovarian follicles. The aetiology is unknown, but may be due either to enhanced follicular growth, reduced atresia, or both. Hyperandrogenism is almost universal either clinically or biochemically and in primates and sheep androgen excess in-utero produces ovaries phenotypically identical to those in PCOS. There have been no analyses of the effects of androgens on early...

ea0011p73 | Clinical case reports | ECE2006

Familial hyperparathyroidism with a mutation in the HRPT2 gene

Goulden P , Bano G , Ajith Kumar VK , Hodgson SV , Nussey SS

A 72 years old lady was referred to endocrine clinic with raised serum calcium of 2.69 mmol/l and PTH of 99.6 ng/l (3.0–48.0 ng/l) detected during investigations for an abnormal skeletal survey. She was known to have osteoporosis from the age of 59 diagnosed on Dexa scan. Case notes revealed raised serum calcium of 2.52–2.60 mmol/l since year 2000. Her repeat serum calcium was 2.77 mmol/l with phosphate of 1.03 mmol/l and 25 hydroxy vitamin D of 36 nmol/l. She admitt...

ea0011p74 | Clinical case reports | ECE2006

Pendred’s syndrome with three mutations

Goulden P , Bano G , Ajith Kumar VK , Hodgson SV , Nussey SS

This 48-year-old with consanguineous parentage presented at the age of 23 in 1980 with congenital bilateral sensorineural deafness and hypothyroidism requiring replacement with 150 mcg thyroxine. There was a family history of deafness and thyroid disease. A perchlorate discharge test was performed and 42% of the radioiodine within the gland was discharged by potassium perchlorate (NR <10%).Over the following decade she developed a diffuse goitre whic...