Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep305 | Calcium & Vitamin D metabolism | ECE2017

Pseudohypoparathyroidism (PHP) and GNAS gene mutations – clinical spectrum from PHP type 1a to pseudopseudohypoparathyroidism

Saavedra Ana , Rodrigues Elisabete , Cunha Filipe , Leao Miguel , Carvalho Davide

Introduction: Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of disorders that have in common end-organ unresponsiveness to parathyroid hormone (PTH). The most frequent form, PHP type 1, results from different genetic/epigenetic changes in the GNAS gene.Case 1: Woman, 25 years-old, sent to Endocrinology from Genetics consultation after her daughter had been diagnosed with PHP type 1a (heterozygous pathogenic variant at exon 13 of...

ea0049ep1206 | Clinical case reports - Thyroid/Others | ECE2017

Amyloid goiter secondary to Crohn’s disease

Saavedra Ana , Rodrigues Elisabete , Marques Ana , Carvalho Davide

Introduction: Amyloidosis results from deposition of insoluble proteins in the extracellular space. It can be both primary or secondary to chronic inflammatory diseases. Although microscopic thyroid involvement is common, cases in which it becomes clinically evident (amyloid goiter) are rare.Case report: Woman, 45 years. In 2009, she was diagnosed with Crohn’s disease after Bartholin’s gland abscess excision and evaluation for weight loss, anem...

ea0041ep722 | Male Reproduction | ECE2016

Hypogonadotropic hypogonadism – clinical spectrum: from sporadic to familiar forms

Saavedra Ana , Rodrigues Elisabete , Lemos Manuel , Carvalho Davide

Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder. It can be sporadic or familiar and is divided into anosmic hypogonadotropic hypogonadism (Kallmann syndrome - KS) and congenital normosmic isolated hypogonadotropic hypogonadism (idiopathic hypogonadotropic hypogonadism ‐ IHH). A growing number of genes are involved in its etiology, suggesting the heterogeneity and complexity of this condition.Cases Reports: Six cases...

ea0041ep1104 | Thyroid cancer | ECE2016

Thyroid cancer in hyperthyroid patients treated by surgery

Domingues A L , Rodrigues E , Saavedra A , Matos Lima L , Carvalho D

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...

ea0035p936 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Dilated cardiomiopathy and acromegaly

Saavedra Ana , Goncalves Helena , Pereira Josue , Vinha Eduardo , Carvalho Davide

Introduction: Chronic somatotropin (ST) hypersecretion has systemic effects. It can cause important structural and functional cardiovascular (CV) changes, which can result in increased morbidity and mortality.Case report: A 48-year-old, male. followed by cardiology since 2005 for dilated cardiomyopathy (DCM) (Ecocardiography: moderately dilated left ventricle with globular appearance. Severely impaired global systolic function - LVEF 25%. Right cavities ...

ea0037ep1243 | Clinical Cases–Pituitary/Adrenal | ECE2015

Acromegaly caused by atypical pituitary adenoma

Costa Maria Manuel , Saavedra Ana , Castro Ligia , Basto Margarida , Pereira Josue , Vinha Eduardo , Carvalho Davide

Introduction: Atypical pituitary adenomas have higher risk of aggressive behaviour in particular by the higher growth, local invasion and high risk of recurrence after surgery. In acromegaly the resistance to somatostatin analogues may be another manifestation of these adenomas since higher levels of Ki-67 are associated with poor response to therapy.Case report: A 41-year-old woman presented to our consult with history of headaches, growth of the hands,...

ea0037ep1299 | Clinical Cases–Thyroid/Other | ECE2015

Graves' orbitopathy coursing with hypothyroidism: a case-report

Saavedra Ana , Nunes Joana Menezes , Rodrigues Elisabete , Ribeiro Sara , Leal Victor , Carvalho Davide

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

ea0056p1044 | Thyroid (non-cancer) | ECE2018

Usefulness of ultrasound evaluation of thyroid nodules in predicting malignancy

Atienza Elena , Trifu Daniela Stefania , Tasende Clara , Escribano Pablo , Saavedra Pilar , Rubio Jose Antonio , Blanco Concepcion

Introduction: Ultrasound (US) thyroid examination is the most common method to assess thyroid nodules risk of malignancy and select nodules for fine-needle aspiration biopsy (FNAB). Thyroid US evaluation performed by endocrinologists has recently increased in Spain.Objectives: To evaluate the predictive value of US features of malignancy in differentiating benign and malignant thyroid lesions in a Thyroid Nodule Clinic.Patients and...

ea0090ep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The influence of the endocrinologist in the management of type 2 diabetes

Martinez Silvia Gonzalez , Escobedo Raul Rodriguez , Kuzior Agnieszka , Montero Paula Aristegui , Ojeda Aida Saavedra , Martin Roque Daniel

Introduction: In Spain, the specialist in endocrinology and nutrition is the reference in the care of patients with diabetes mellitus. In the year 2022, access to these specialists has been facilitated in the south of Gran Canaria. The aim of the study is to determine how this has influenced the management of type 2 diabetes (T2D).Methods: We included those patients with T2D assessed by the Endocrinology service in 2022 in which two analyses were perform...

ea0049ep1058 | Pituitary - Clinical | ECE2017

Clinical and laboratorial reassessment of patients with isolated growth hormone deficiency during the transition phase

Saavedra Ana , Oliveira Juliana , Martins Alexandra , Azevedo Ana , Santos-Silva Rita , Castro Cintia , Rodrigues Elisabete , Carvalho Davide , Fontoura Manuel

Introduction: During childhood and puberty, growth hormone(GH) is essential for linear growth. Consequently, children with isolated GH deficiency(GHD) must receive replacement therapy. GH has also important metabolic actions. GHD in adults is associated with altered body composition. However, long-term consequences of GH treatment in adults is not sufficiently known.Objective: To evaluate GH treatment during pediatric age in patients with isolated GHD.</...