Endocrine Abstracts

Introduction: Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of disorders that have in common end-organ unresponsiveness to parathyroid hormone (PTH). The most frequent form, PHP type 1, results from different genetic/epigenetic changes in the GNAS gene.Case 1: Woman, 25 years-old, sent to Endocrinology from Genetics consultation after her daughter had been diagnosed with PHP type 1a (heterozygous pathogenic variant at exon 13 of...

Introduction: Amyloidosis results from deposition of insoluble proteins in the extracellular space. It can be both primary or secondary to chronic inflammatory diseases. Although microscopic thyroid involvement is common, cases in which it becomes clinically evident (amyloid goiter) are rare.Case report: Woman, 45 years. In 2009, she was diagnosed with Crohn’s disease after Bartholin’s gland abscess excision and evaluation for weight loss, anem...

Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder. It can be sporadic or familiar and is divided into anosmic hypogonadotropic hypogonadism (Kallmann syndrome - KS) and congenital normosmic isolated hypogonadotropic hypogonadism (idiopathic hypogonadotropic hypogonadism ‐ IHH). A growing number of genes are involved in its etiology, suggesting the heterogeneity and complexity of this condition.Cases Reports: Six cases...

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...

Introduction: Chronic somatotropin (ST) hypersecretion has systemic effects. It can cause important structural and functional cardiovascular (CV) changes, which can result in increased morbidity and mortality.Case report: A 48-year-old, male. followed by cardiology since 2005 for dilated cardiomyopathy (DCM) (Ecocardiography: moderately dilated left ventricle with globular appearance. Severely impaired global systolic function - LVEF 25%. Right cavities ...

Introduction: Atypical pituitary adenomas have higher risk of aggressive behaviour in particular by the higher growth, local invasion and high risk of recurrence after surgery. In acromegaly the resistance to somatostatin analogues may be another manifestation of these adenomas since higher levels of Ki-67 are associated with poor response to therapy.Case report: A 41-year-old woman presented to our consult with history of headaches, growth of the hands,...

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

Introduction: Ultrasound (US) thyroid examination is the most common method to assess thyroid nodules risk of malignancy and select nodules for fine-needle aspiration biopsy (FNAB). Thyroid US evaluation performed by endocrinologists has recently increased in Spain.Objectives: To evaluate the predictive value of US features of malignancy in differentiating benign and malignant thyroid lesions in a Thyroid Nodule Clinic.Patients and...

Introduction: In Spain, the specialist in endocrinology and nutrition is the reference in the care of patients with diabetes mellitus. In the year 2022, access to these specialists has been facilitated in the south of Gran Canaria. The aim of the study is to determine how this has influenced the management of type 2 diabetes (T2D).Methods: We included those patients with T2D assessed by the Endocrinology service in 2022 in which two analyses were perform...

Introduction: During childhood and puberty, growth hormone(GH) is essential for linear growth. Consequently, children with isolated GH deficiency(GHD) must receive replacement therapy. GH has also important metabolic actions. GHD in adults is associated with altered body composition. However, long-term consequences of GH treatment in adults is not sufficiently known.Objective: To evaluate GH treatment during pediatric age in patients with isolated GHD.</...