Searchable abstracts of presentations at key conferences in endocrinology

ea0056p592 | Obesity | ECE2018

Activation of p53 with low doses doxorubicin reduce the acumulation of lipids in two in vitro models of liver steatosis

Fernandez Fondevila Marcos , Porteiro Coto Begona , Buque Xabier , Jesus Gonzalez Rellan Maria , Fernandez Paz Uxia , Mora Alfonso , Beiroa Daniel , Senra Ana , Gallego Rosalia , Lopez Miguel , Sabio Guadalupe , Dieguez Carlos , Aspichueta Patricia , Nogueiras Pozo Ruben

Introduction: p53 is transcription factor widely known because of its antitumoral actions. New evidences suggest that p53 also play a key role in the regulation of metabolic homeostasis and specifically in the lipid metabolism.Objective: We hypothesize that the chemical activation of p53 with low doses of doxorubicin could ameliorate the lipid metabolism in in vitro models of liver steatosis.Methods: We treated with low co...

ea0032p681 | Neuroendocrinology | ECE2013

Hypothalamic melanin-concentrating hormone influences liver and adipose lipid metabolism

Imbernon Monica , Beiroa Daniel , Vazquez Maria J , Morgan Donald A , Veyrat-Durebex Christelle , Porteiro Begona , Diaz-Arteaga Adenis , Senra Ana , Al-Massadi Omar , Velasquez Douglas A , Gallego Rosalia , Seoane Luisa M , Lopez Miguel , Davis Roger J , Sabio Guadalupe , Rohner-Jeanrenaud Francoise , Rahmouni Kamal , Dieguez Carlos , Nogueiras Ruben

Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...

ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

p63 induces the fibrosis in NASH

Fondevila Marcos F , Novoa Eva , Uxía Fernández , María J González-Rellán , Lima Natalia , Begoña Porteiro , Juan Cuñarro , Tovar Sulay , Fidalgo Miguel , Martinez-Chantar Maria Luz , Sabio Guadalupe , Marcos Miguel , Lopez Miguel , Dieguez Carlos , Rubén Nogueiras

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

ea0073aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Inhibition of ATG3 ameliorates liver steatosis by increasing SIRT1 in an autophagic-independent action

Novoa Eva , Nátalia da Silva Lima , Marcos Férnandez Fondevila , Buque Xabier , María Jesús González Rellán , Uxía Fernández Paz , María García Vence , María del Pilar Chantada Vázquez , Bravo Susana , Patricia Marañon , Escudero Adriana , Leiva Magdalena , Fidalgo Miguel , Gomes Pedro , Claret Marc , Sabio Guadalupe , Rey Marta Varela , Delgado Teresa , Miguel López , Carlos Diéguez , María Martínez Chantar , Carmelo García Monzon , Agueda González Rodríguez , Aspichueta Patricia , Rubén Nogueiras Pozo

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...