Searchable abstracts of presentations at key conferences in endocrinology

ea0050ep028 | Bone and Calcium | SFEBES2017

A rare case of hypercalcaemia: Double trouble, with a twist

Sagar Rebecca , Abbas Afroze

This gentleman originally presented at the age of 60 years old with slurred speech, confusion and cerebellar signs and was found to have raised calcium and PTH. His sisters, son and daughter were known to have hyperparathyroid-jaw tumour syndrome (HPT-JT) due to a novel germline Leu63Pro missense mutation in CDC73 exon 2. An MRI brain identified cerebellar lesions and he had positive voltage gated potassium channels; both of indeterminate aetiology follo...

ea0050ep028 | Bone and Calcium | SFEBES2017

A rare case of hypercalcaemia: Double trouble, with a twist

Sagar Rebecca , Abbas Afroze

This gentleman originally presented at the age of 60 years old with slurred speech, confusion and cerebellar signs and was found to have raised calcium and PTH. His sisters, son and daughter were known to have hyperparathyroid-jaw tumour syndrome (HPT-JT) due to a novel germline Leu63Pro missense mutation in CDC73 exon 2. An MRI brain identified cerebellar lesions and he had positive voltage gated potassium channels; both of indeterminate aetiology follo...

ea0049ep334 | Clinical case reports - Thyroid/Others | ECE2017

Broken bones and blindness- a rare cause of osteoporosis

Sagar Rebecca , Abbas Afroze

Case History: A 37 year-old gentlemen was referred to metabolic bone clinic due to recurrent recent fragility fractures. He had several fractures throughout childhood, and these had continued to occur into his adult life. He was blind in his left eye since birth. He felt that this had contributed to his fractures, due to falls. There had been no other previous major health problems. His brother had a similar eye condition. There were no other risk factors for osteoporosis. The...

ea0048o10 | Oral Communications | SFEEU2017

Broken bones and blindness – a rare cause of osteoporosis

Sagar Rebecca , Abbas Afroze

Case History: A 37-year-old gentlemen was referred to metabolic bone clinic due to recurrent recent fragility fractures. He had suffered several fractures throughout childhood, and these had continued to occur into his adult life. He was blind since birth in his left eye. He felt that this had contributed to his fractures due to falls and other accidents. There had been no other major health problems in the past. His brother had a similar eye condition. There were no other ris...

ea0056p44 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency in treated PMR: The tip of the iceberg

Sagar Rebecca , Abbas Afroze

Background: Prolonged, high dose glucocorticoid therapy is used in to treat a number of rheumatological diseases, including polymyalgia rheumatica (PMR), giant-cell arteritis (GCA) and large vessel vasculitis (LVV). However there can be significant consequences of long-term glucocorticoid use, including iatrogenic adrenal insufficiency, due to suppression of the hypothalamic-pituitary-adrenal axis. This study aims to evaluate the prevalence, investigation and recovery of iatro...

ea0065p32 | Adrenal and Cardiovascular | SFEBES2019

An unusual case of adrenal cortical carcinoma presenting with hypogonadotrophic hypogonadism

Sagar Rebecca , Gibbons Stephen , Abbas Afroze

We report the case of a 52 year old gentleman who presented to Primary Care with a short history of gynaecomastia, loss of libido and erectile dysfunction. He was normally fit and well, with no past medical history and no regular medications. Initial blood tests showed low testosterone (0.7 nmol/l (normal 11–28)) with inappropriately low gonadotrophins (LH 1.2iU/l (1.5–9.3), FSH <0.1 iU/l (1.4–18.1)). Other blood tests were unremarkable (TFTs, prolactin, FBC...

ea0049ep280 | Calcium &amp; Vitamin D metabolism | ECE2017

Management of primary hyperparathyroidism: Experience of a large UK teaching hospital

Sagar Rebecca , Longhurst Amy , Abbas Afroze

Background: Primary hyperparathyroidism (PHPT) is a common cause of hypercalcaemia seen in outpatient endocrinology clinic. Diagnosis is based on biochemistry and exclusion of other conditions, such as familial hypocalciuric hypercalcaemia. Symptomatic patients should usually be referred for parathyroidectomy. For asymptomatic patients there are clear guidelines for surgical referral, based on the Fourth International Workshop (2014) recommendations. This study evaluates curre...

ea0086p19 | Adrenal and Cardiovascular | SFEBES2022

An Audit of Adrenal Vein Sampling in a large teaching hospital in Leeds

Lim Joyce , Sagar Rebecca , Abbas Afroze

Introduction: Primary hyperaldosteronism (PA) can affect up to 10% of patients with hypertension. Adrenal vein sampling (AVS) is used to distinguish between unilateral and bilateral aldosterone production. However, it is invasive, technically challenging and is only performed in a limited number of centres. This audit aimed to evaluate the effectiveness of AVS in informing the management of PA in a large teaching hospital.Methods: A retrospective audit o...

ea0077p31 | Bone and Calcium | SFEBES2021

Recombinant PTH 1-84 (Natpar) treatment in a case of refractory hypocalcaemia secondary to surgical hypoparathyroidism and malabsorption post-gastric bypass

Sagar Rebecca , Cooke Heather , Maguire Deidre , Abbas Afroze

We report the case of a 63-year-old lady with refractory hypocalcaemia due to surgical hypoparathyroidism, decompensated by malabsorption following gastric bypass, successfully treated with recombinant human parathyroid hormone 1-84 (rhPTH), Natpar. She initially presented with medullary thyroid cancer aged 33 and was found to have MEN2A. She underwent thyroidectomy and developed post-surgical hypoparathyroidism. She was managed for over 20 years with alfacalcidol and oral cal...

ea0081p523 | Adrenal and Cardiovascular Endocrinology | ECE2022

A retrospective evaluation of the utility of overnight dexamethasone suppression tests in over 500 patients evaluated for hypercortisolism

Sagar Rebecca , Elsabbagh Mohamed , Gibbons Stephen , Abbas Afroze

Background: Overnight dexamethasone suppression tests (ONDST) are conducted to investigate patients with symptoms suggestive of cortisol hypersecretion or if an adrenal incidentaloma is identified. Cortisol levels of 50 nmol/l and above following ONDST may be related to autonomous cortisol secretion (ACS) and require further investigation. Determining likely presence of ACS is essential given reported associations with type 2 diabetes mellitus (T2DM), obesity, cardiovascular d...