Searchable abstracts of presentations at key conferences in endocrinology

ea0055cb15 | Additional Cases | SFEEU2018

A rare cause of elevated testosterone levels in an adult female

Hussain Shazia , Sahdev Anju , Drake William

A 49 year old Russian lady was found to have an elevated testosterone level (9 nmol/l) when investigated for hair loss. This was first detected some years ago when she apparently was given a provisional diagnosis of polycystic ovarian syndrome. When assessed in her local endocrine unit she did not report any excessive body hair growth or symptoms of virilisation. She claimed to reach the menopause aged 45 years and reported a family history of early menopause. Initial blood te...

ea0069oc5 | Oral Communications | SFENCC2020

A Rare Adrenal Tumour Presenting as an Adrenal Incidentaloma

Seguna Desiree , Hawthorne Mark , Parvanta Leila , Sahdev Anju , Berney Daniel , Waterhouse Mona

Case history: An 18-year old lady being investigated for anaemia, was incidentally found to have a 15 cm left adrenal mass. History taking revealed a 6-month history of weight gain, fatigue, and hirsutism. Past medical history was positive for mental illness. There was no learning disability or history of epilepsy. Physical examination was unremarkable.Investigations: Biochemical work-up for a functional adenoma revealed normal serum cortisol and circadi...

ea0069p61 | Poster Presentations | SFENCC2020

A case of pulmonary neuroendocrine tumours secreting ACTH and GHRH

Lee Yun-Ni , Jiwan Riyah , Sahdev Anju , Berney Daniel , Wilson Henrietta , Akker Scott , Davies Zoe

Section 1: Case history: A sixty-three-year-old Caucasian male presented with a six-week history of lethargy, emotional lability, polydipsia, polyuria, increased appetite and weight gain. He also reported changes in his facial features and widening of the gaps between his teeth. He has a background of hypertension, obstructive sleep apnoea and benign prostatic hyperplasia. On examination, the patient appeared plethoric, had coarsened facial features, mild prognathism and evide...

ea0048wh2 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2017

An unusual presentation of multiple endocrine neoplasia 1 (MEN1)

Pittaway James , Sahdev Anju , Harrison Barney , Newell-Price John , Drake William

Case history: A 36 year-old man was referred to our department for further evaluation of a large adrenal and multiple liver mass lesions. These had been found on an abdominal ultrasound requested for a 3 week history of mild, episodic abdominal pain. He was asymptomatic but described mild night sweats for over 10 years.Investigations, results and treatment: Hyperparathyroidism was evident, with a serum corrected calcium 3.04 mmol/l (2.15–2.65), PTH ...

ea0070aep641 | Pituitary and Neuroendocrinology | ECE2020

Medical treatment leading to remission of ectopic cushing’s syndrome

Seguna Desiree , Shiafkou Marianna , Sahdev Anju , Al-Mrayat Ma’en , Akker Scott

A 35 year-old lady presented to her local hospital with a 3 year history of fatigue, weight gain, recurrent tonsillitis and oligomenorrhoea. Examination revealed facial plethora, round facies and thin skin on the dorsum of the hand. She appeared tanned, with evidence of spontaneous bruising and difficulty standing up from a chair unaided. No striae were present. Blood pressure was 152/91 mmHg. Investigations revealed a 0900 h cortisol of 632 nmol/l (ACTH 59 ng/l) and an elevat...

ea0034p188 | Neoplasia, cancer and late effects | SFEBES2014

SDHB surveillance regime: a single UK institution experience

Srirangalingam Umasuthan , Khan Fazia , Gunganah Kirun , Sahdev Anju , Waterhouse Mona , Druce Maralyn R , Drake William M , Akker Scott A

Background: Succinate dehydrogenase B (SDHB) associated disease has been characterised by the presence of extra-adrenal paragangliomas with a high rate of metastatic transformation. There is currently no consensus as to the appropriate surveillance regimes for these subjects. We present the surveillance data from a single UK institution with an SDHB surveillance regime which includes annual MR imaging of the abdomen, biennial imaging of the neck, thorax and pelvis and annual u...

ea0077p142 | Adrenal and Cardiovascular | SFEBES2021

Clinical prediction scores in primary aldosteronism reliably identify a subset of patients with bilateral disease avoiding the need for adrenal venous sampling

Munro Colin , Akker Scott , Druce Maralyn , Sze Wing-Chiu , Waterhouse Mona , Sahdev Anju , Matson Matthew , Parvanta Laila , Drake William , O’Toole Sam

Introduction: Primary aldosteronism (PA) is both the most common form of secondary hypertension and a high-risk subset associated with increased cardiovascular, cerebrovascular and renal morbidity compared to essential hypertension. Unilateral PA is amenable to surgery, biochemical cure and reversal of this excess risk; whilst bilateral disease is best treated through mechanism-directed medical therapy. Currently, PA subtype classification relies on adrenal venous sampling (AV...

ea0065p144 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

The yield and cost of radiological screening in von Hippel–Lindau disease

McMillan Timothy , Sahdev Anju , Evanson Jane , McAndrew Lorraine , Martin Lee , Paraskevopoulos Dimitrios , Bull Jonathan , Parvanta Laila , Gevers Evelien , Drake William , O'Toole Samuel

Introduction: Patients with the familial cancer syndrome von Hippel–Lindau disease (VHL) are enrolled in radiological screening programmes which aim to identify tumour development at an early stage. This facilitates timely intervention to lesions when the risk of metastatic spread is low and when they are conducive to less-invasive and parenchymal-sparing interventions, thereby minimising treatment-related morbidity. A number of international screening protocols exist, al...

ea0044p5 | Adrenal and Steroids | SFEBES2016

Outcomes of annual surveillance imaging in an adult and paediatric cohort of succinate dehydrogenase B mutation carriers

Tufton Nicola , Shapiro Lucy , Srirangalingam Umasuthan , Richards Polly , Sahdev Anju , Kumar V K Ajith , Chew Shern L , Drake William M , Storr Helen , Akker Scott A

Introduction: Germline mutations in succinate dehydrogenase subunit B (SDHB) are one of the commonest findings in familial paraganglioma (PGL) syndromes and account for one quarter of PGLs associated with germline mutations. Although the penetrance is low, the malignancy conversion is high; up to 30%. With the increasing availability of genetic testing and the identification of ‘asymptomatic carriers’ of the SDHB gene mutation, it is therefore impor...

ea0086p7 | Adrenal and Cardiovascular | SFEBES2022

Adrenalectomy for unilateral primary aldosteronism improves quality of life: prospective analyses in the MATCH trial

Blackstone Brittany , Goodchild Emily , Tooze Oliver , Salsbury Jackie , Wu Xilin , Ronaldson Amy , Senanayake Russell , Bashari Waiel , Argentesi Giulia , O'Toole Samuel M. , Parvanta Laila , Sahdev Anju , Laycock Kate , Cruickshank Kennedy , Gurnell Mark , M. Drake William , Brown Morris J.

Background: After adrenalectomy (ADX) for primary aldosteronism (PA), approximately 30% of patients achieve clinical success (normalisation of home BP); many additional patients report feeling subjectively better. We used the non-randomised MATCH study1 to further assess quality of life (QoL) changes in participants.Objective: Assess QoL using the 36-item Short Form Health Survey (SF-36) after surgical treatment of unilateral PA and medical treatment of ...