Searchable abstracts of presentations at key conferences in endocrinology

ea0028oc5.7 | Growth, tumours and pituitary | SFEBES2012

The role of the familial pituitary adenoma gene, AIP, in the proliferative and invasive activity of a malignant pancreatic cell line

Saleh Jumana , Barry Sayka , Korbonits Marta

Background: Heterozygote mutations in the aryl hydrocarbon receptor-interacting protein (AIP) predispose carriers to young-onset pituitary adenomas, most often somatotroph or lactotroph adenomas. No other tumour type has been consistently detected in AIP mutation positive families, despite the fact that AIP is ubiquitously expressed. Current clinical and experimental data suggest that AIP is a tumour suppressor gene.Aims: To investigate the tumour suppre...

ea0044p198 | Obesity and Metabolism | SFEBES2016

Progesterone and estrogen regulation of gene expression related to acylation stimulating protein production and function in ex vivo adipose tissue explant culture

Al Riyami Bashair , Langley-Evans Simon , Salter Andrew , Saleh Jumana

Acylation stimulating protein (ASP) synthesis occurs through the interaction between complement C3, factor B and adipsin in adipose tissue. ASP demonstrates potent lipogenic effects that are modulated by sex hormones in vivo and in vitro. In this study, an ex vivo investigation was carried out to analyse expression of genes related to ASP production and function. Adipose tissue was harvested from ovariectomized rats (n=6), and treated with s...

ea0038fp11 | (1) | SFEBES2015

Potential molecular mechanism of AIP-mediated cellular invasion

Barry Sayka , Carlsen Eivind , Saleh Jumana A , Gadaleta Emanuela , Chelala Claude , Korbonits Marta

Background: Heterozygote germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) gene play a role in the pathogenesis of pituitary adenoma development in familial isolated pituitary adenoma as well as simplex pituitary adenoma cases. AIP mutation positive patients develop often aggressively growing tumours in early teenage years.Aims: The aim of this study was to perform comparative gene expression analysis of AIP mutation-positive ...