Searchable abstracts of presentations at key conferences in endocrinology

ea0009oc40 | Oral Communication 5: Thyroid | BES2005

Development of novel thyroid stimulating monoclonal antibodies from an experimental model with potencies equivalent to those in Graves' disease patients, including full agonistic activity but also differential blocking properties

Gilbert J , Rao P , Salehi S , Gora M , McGregor A , Banga J

In Graves' disease (GD), it is recognised that isolation of the rare pathogenic autoantibodies that stimulate the thyrotropin receptor (TSHR) would assist in understanding disease pathogenesis. To date, monoclonal antibodies (mabs) to the TSHR with thyroid stimulating activity (TSAbs) have been isolated from experimental models of GD which are 100 fold weaker than the reported single human mab with strong TSAb activity. We describe two novel IgG mabs from a murine model of GD ...