Searchable abstracts of presentations at key conferences in endocrinology

ea0063s6.2 | A better life with thyroid hormone (Endorsed by the European Journal of Endocrinology) | ECE2019

Subclinical hypothyroidism in children

Salerno Mariacarolina

Subclinical hypothyroidism (SH) is a biochemical condition defined by increased TSH serum concentration above the normal range associated with normal concentrations of T4 and Free T4. In children SH is often a benign and remitting condition, for which risk of progression to overt hypothyroidism depends on the underlying cause (i.e. autoimmune SH is associated with an increased risk whereas non–autoimmune with a low risk of progression to overt hypothyroidism). The major c...

ea0037s4.1 | Thyroid hormone and cardiovascular system | ECE2015

Subclinical hypothyroidism and cardiovascular consequences in childhood

Salerno Mariacarolina

The relationship between subclinical hypothyroidism (SH) and cardiovascular (CV) risk is still matter of debate. While the key-role of thyroid hormones in modulation of several atherosclerotic factors is well established, the mechanisms of TSH’s action on CV system are still largely unknown.In adults with SH a pattern of CV abnormalities (dyslipidemia, insulin resistance, endothelial and diastolic dysfunction) has been observed even in mild SH cases...

ea0063gp52 | Acromegaly and GH | ECE2019

Final height in childhood onset hypopituitarism

Esposito Andrea , Improda Nicola , Moracas Cristina , Barbieri Flavia , Alfano Sara , Capalbo Donatella , Salerno Mariacarolina

Background: Growth hormone (GH) deficiency(GHD) in childhood is associated with impairment in linear growth. GH therapy enables the achievement of normal adult height in most cases. The response is variable and factors influencing height outcome are still not clearly defined.Objective: To evaluate near adult height (NAH) in a single center cohort of childhood onset GHD patients treated with GH and investigate main predictors of final height (FH).<p c...

ea0063gp60 | Acromegaly and GH | ECE2019

Metabolic outcome in adolescents with growth hormone deficiency during transition phase

Improda Nicola , Anselmi Federica , Alfano Sara , D'Acunzo Ida , Bufalo Lorenzo , Capalbo Donatella , Salerno Mariacarolina

Background: There is concern that adolescents with childhood-onset GHD (COGHD) and persistent GH deficiency may be exposed to multiple metabolic risks after GH treatment withdrawal at the attainment of final height (FH).Aim: Aim of our study is to retrospectively compare growth response and metabolic profile in isolated idiopathic COGHD adolescents with permanent GH deficiency in comparison to GHD subjects who normalized their GH response at transition p...

ea0063p293 | Pituitary and Neuroendocrinology 1 | ECE2019

Long-term effects of GH replacement therapy on thyroid function in children with GH deficiency

D'Acunzo Ida , Anselmi Federica , Gaeta Valeria , Barbieri Flavia , Ciccarelli Gian Paolo , Improda Nicola , Salerno Mariacarolina

Background: Several studies have investigated the effects of GH replacement therapy (GHRT) on thyroid function in children with GH deficiency (GHD) leading to contrasting results. Indeed, GHRT has been reported to affect the peripheral metabolism of thyroid hormones, to alter TSH secretion by pituitary and to unmask secondary hypothyroidism.Objective: To evaluate long-term effects of GHRT on thyroid function in a large cohort of GHD children.<p class...

ea0063p398 | Thyroid 1 | ECE2019

Intellectual outcome in children with subclinical hypothyroidism: effects of two years of levothyroxine treatment

Ciccarelli Gian Paolo , Improda Nicola , Anselmi Federica , Polizzi Miriam , Bravaccio Carmela , Capalbo Donatella , Salerno Mariacarolina

Introduction: Subclinical hypothyroidism (SH) is characterized by serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4. Associ-ation between SH in childhood and adverse neurocognitive outcomes remains controversial.Objective: To evaluate the intellectual outcome of children with SH before and after 2 years of treatment with levothyroxine (L-T4).Methods...

ea0063p399 | Thyroid 1 | ECE2019

Cardiac size and function in children with subclinical hypothyroidism

Alfano Sara , D'Acunzo Ida , Cittadini Antonio , Capalbo Donatella , Improda Nicola , Salerno Mariacarolina

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L. Although SH in children seems to be a bening condition, ongoing scientific investigations have highlighted the presence of subtle proatherogenic abnormalities among children with modest elevations in their TSH levels. Data on cardiac performance in children with SH are still scanty.Aim: To compar...

ea0063p400 | Thyroid 1 | ECE2019

Bone homeostasis in children with Subclinical hypothyroidism: effects of two-years treatment with levothyoxine

Gaeta Valeria , Bufalo Lorenzo , Lorello Paola , Mase Raffaella Di , Capalbo Donatella , Salerno Mariacarolina

Background: Thyroid hormone plays a key role in bone mineral homeostasis and significant alterations in its circulating levels has been associated with impairment in skeletal growth during childhood. To date, bone effects of subclinical hypothyroidism (SH) has not been demonstrated yet, therefore the management of this condition is still debated.Aim: To evaluate bone mineral density (BMD) in children with mild, persistent SH and the effects of two-years ...

ea0063p659 | Interdisciplinary Endocrinology 1 | ECE2019

Long-term outcome in young women treated for central precocious puberty

Improda Nicola , Barbieri Flavia , Moracas Cristina , Paolo Ciccarelli Gian , Capalbo Donatella , Santamaria Fabiana , Salerno Mariacarolina

Background: GnRH-analogs (GnRHa) are the recommended treatment for Central Precocious Puberty (CPP). Despite a normal long-term outcome is generally reported, reproductive function and emotional sphere in adulthood are still poorly evaluated.Objective: To evaluate the general long-term outcome of young women with previous CPP treated with GnRHa.Patients and methods: A cohort of 63 young women (25.5±5.31 years) with history of ...

ea0063p684 | Pituitary and Neuroendocrinology 2 | ECE2019

Effects of growth hormone deficiency (ghd) and gh treatment on early markers of atherosclerosis in children

Barbieri Flavia , Improda Nicola , Esposito Andrea , Moracas Cristina , Gaeta Valeria , Salerno Mariacarolina

Background: Endothelial dysfunction is considered an early step in the development of atherosclerosis, while an increased intima-media thickness (IMT) represents one of the earliest morphological changes in the arterial wall in the process of atherogenesis. Only a few studies have investigated endothelial dysfunction and IMT in GHD children and results are still inconsistent.Objective: Aim of our study was to evaluate the effects of GHD and GH treatment ...