Endocrine Abstracts

Cushing syndrome is a comorbid condition resulting from long-term exposure to glucocorticoids (GC). It affects body fat composition in various parts of the body. Since each fat depot has a distinct response to glucocorticoid exposure, we wanted to understand adipose tissue turnover. In order to reproduce the disease state, we used a rodent model recapitulating Cushing syndrome. We inserted subcutaneous mini pumps in the dorsal area of rats to infuse Dexamethasone at a rate of ...