Searchable abstracts of presentations at key conferences in endocrinology

ea0006oc6 | Young Endocrinologist Session | SFE2003

Crosstalk between IGF signalling and cadherin-mediated cell adhesion promotes myogenic differentiation

Lovett F , Gonzalez M , Carter E , Cobb L , Salih D , Tripathi G , Holding C , Pell J

The IGF-I receptor (IGF-IR) growth/survival pathways are engaged in crosstalk with pathways induced by cell-cell interactions. Different elements of the IGF-IR signalling system also affect the phosphorylation status of molecules involved in the regulation of cadherin-mediated cell-cell adhesion, such as catenins. In addition, the IGF-IR has been shown to co-precipitate with cell adhesion complexes.In this study, the crosstalk between IGF signalling and ...

ea0006oc16 | Growth and Development | SFE2003

Overexpression of insulin-like growth factor binding protein-5 (Igfbp5) in mice results in compromised muscle development

Salih D , Holding C , Tripathi G , Cobb L , Gonzalez I , Carter E , Lovett F , Pell J

Igfbp5 is the most conserved of the six members of the Igfbp family, which orchestrate the actions of the insulin-like growth factors (IGFs) systemically via blood and locally within tissues. Igfbp5 is upregulated in key lineages during development (e.g. muscle) and pathologies (e.g. rhabdomyosarcoma).To highlight the range and extent of Igfbp5 actions in vivo, we generated novel lines of transgenic mice t...

ea0003oc18 | Growth Regulation | BES2002

Overexpression of insulin-like growth factor binding protein-5 (IGFBP-5) induces severe growth retardation in transgenic mice

Salih D , Szestak T , Carter E , Gonzalez I , Eisemann J , Pell J

IGFBP-5 is the most conserved of a family of high affinity proteins that modulate IGF activity. It is upregulated in key lineages during their differentiation and development. In addition to domains associated with IGF binding, IGFBP-5 also possesses motifs that may be involved with its recently demonstrated IGF-independent actions. We have therefore examined the hypothesis that IGFBP-5 is important during development. We have generated mice overexpressing IGFBP-5 using an ear...