Searchable abstracts of presentations at key conferences in endocrinology

ea0086p275 | Reproductive Endocrinology | SFEBES2022

Follicle Sizes That are Most Likely to Yield Oocytes During In Vitro Fertilisation (IVF) Treatment

Alhamwi Toulin , Abbara Ali , Hanassab Simon , Comninos Alexander , Kelsey Tom , Salim Rehan , Heinis Thomas , Dhillo Waljit

Background: Infertility affects 1 in 6 couples causing devastating psychological impact. In vitro fertilisation (IVF) treatment can aid couples to conceive, but personalisation of treatment is needed to optimise patient outcomes. Machine learning can aid in the analysis of large complex datasets such as those encountered during IVF treatment. One example is in determining the optimal follicle size on the day of trigger to maximise the number of oocytes collected. Both follicle...

ea0059p199 | Reproduction | SFEBES2018

Recombinant FSH dosing during controlled ovarian stimulation in IVF treatment

Patel Aaran , Abbara Ali , Chia Germaine , Eng Pei , Phylactou Maria , Clarke Sophie , Comninos Alexander , Trew Geoffrey , Kelsey Tom , Salim Rehan , Dhillo Waljit

Background: During IVF treatment, a pharmacological dose of recombinant FSH (rFSH) is used to induce multi-follicular growth (controlled ovarian stimulation; COS). An insufficient dose of rFSH negatively impacts the number of oocytes retrieved, whereas an excessive dose risks the potentially life-threatening complication ‘ovarian hyperstimulation syndrome’. Hence, appropriate rFSH dosing is regarded as a key treatment decision affecting both the success and safety of...

ea0065p350 | Reproductive Endocrinology and Biology | SFEBES2019

Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Eng Pei Chia , Abbara Ali , Phylactou Maria , Clarke Sophie A , Yang Lisa , Mills Edouard , Modi Manish , Papadopoulou Deborah , Plumptre Isabella , Hunjan Tia , Purugganan Kate , Webber Lisa , Salim Rehan , Comninos Alexander N , Dhillo Waljit S

Introduction: Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility and is a common cause of anovulatory subfertility. Kisspeptin is an endogenous neuropeptide that regulates hypothalamic GnRH function. Hypothalamic kisspeptin expression is reduced, and kisspeptin receptor expression is increased, in a rodent model of HA. The kisspeptin analogue MVT-602 has a 3-4-fold longer half-life than native kisspeptin-54 (t1/2 0.5 h). We invest...

ea0044oc6.1 | Pregnancy and Reproductive Health | SFEBES2016

Two doses of kisspeptin improve oocyte maturation and implantation rates compared to a single kisspeptin injection during IVF treatment

Abbara Ali , Clarke Sophie , Islam Rumana , Prague Julia , Comninos Alexander , Narayanaswamy Shakunthala , Papadopolou Deborah , Roberts Rachel , Nesbitt Alexander , Izzi-Engbeaya Chioma , Vimalesvaran Sunitha , Ratnasabapathy Risheka , Salim Rehan , Lavery Stuart , Bloom Stephen , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation is an effective therapy for infertility, but can result in the potentially life-threatening complication, Ovarian Hyper-Stimulation Syndrome (OHSS). We have previously reported that a single injection of kisspeptin results in an LH surge of ~12–14 hrs duration, sufficient to safely induce oocyte maturation, but eliminate OHSS. However, the physiological LH surge in a normal menstrual cycle has a plateaux lasting 24–28 hrs. ...