ea0050p326 | Obesity and Metabolism | SFEBES2017
, Adaikalakoteswari Antonysunil
, Samavat Jinus
, Zammit Victor
, Irshad Zehra
, Saravanan Ponnusamy
Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...