Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1161 | Thyroid 3 | ECE2019

Do patients with differentiated thyroid cancer (DTC) harboring TERT promoter mutation require a more intensive treatment and follow-up? – proposal of a prospective study

Samborski Konrad , Krajewska Jolanta , Rusinek Dagmara , Oczko-Wojciechowska Magdalena , Jarzęb Barbara

Introduction: The importance of telomerase reverse transcriptase promoter (TERTp) mutations in DTC is widely discussed. It has been demonstrated that the presence of TERTp mutations is associated with higher cancer aggressiveness, reflected by lymph node metastases, distant metastases, advanced tumor stage, recurrence, and even disease-specific mortality. Nevertheless, there is no clear evidence-based data demonstrating how to manage these patients. Therefore...

ea0092ps1-01-09 | Cancer | ETA2023

Risk of renal adverse effects in patients with advanced thyroid cancer who are undergoing radiological monitoring, with a particular focus on patients receiving tyrosine kinase inhibitors

Haras-Gil Malgorzata , Samborski Konrad , Ledwon Aleksandra , Kolton Magdalena , Handkiewicz-Junak Daria , Jarzab Barbara , Krajewska Jolanta

Introduction: Systemic treatment of advanced progressing thyroid cancer (TC) is based on molecularly targeted therapy with tyrosine kinase inhibitors (TKIs), mainly inhibitors targeting vascular endothelial growth factor receptors (VEGFR). Such treatment is related to numerous side effects. However, the relationship between TKIs and renal adverse events (RAEs) is unclear. VEGFR inhibitors are associated with proteinuria. In some patients, increased serum creatinine level and t...

ea0099p161 | Thyroid | ECE2024

Differentiated thyroid cancer in pregnancy. A retrospective analysis of newly diagnosed patients

Bulwa Maciej , Samborski Konrad , Kolton Magdalena , Haras-Gil Malgorzata , Jarzab Barbara , Handkiewicz-Junak Daria , Krajewska Jolanta

Introduction: The question of whether pregnancy has any impact on the prognosis of differentiated thyroid cancer diagnosed in pregnant women was addressed mainly in retrospective analyses, which showed no significant differences in overall and progression-free survival between women diagnosed during pregnancy in comparison to women whose thyroid cancer diagnosis was unrelated to pregnancy. Thus, following the recent guidelines, watchful waiting is the preferred option, and sur...

ea0101ps2-14-10 | Clinical thyroid cancer research-2 | ETA2024

Are we able to preoperatively predict low-risk thyroid cancer? a retrospective analysis of preoperative ultrasound in large group of patients

Kolton Magdalena , Haras-Gil Małgorzata , Samborski Konrad , Jarząb Barbara , Handkiewicz-Junak Daria , Krajewska Jolanta

Recently, we have witnessed an increase in the number of new thyroid cancer (TC) cases and thyroid surgeries. Both the ATA 2015 and 2022 Polish guidelines allow sparing treatment in low-risk TC. Nevertheless, most patients are qualified for total thyroidectomy. The aim of the study was to analyze the possibility of preoperative diagnosis of low-risk TC based on ultrasound examination (US).Material and method: A retrospective analysis involved 1043 patien...

ea0101ps1-04-07 | Medullary thyroid cancer-1 | ETA2024

Can haemithyroidectomy be an adequate treatment for nonhereditary medullary thyroid cancer (MTC)?

Kropinska Aleksandra , Langer Macioł Hanna , Cieslicka Marta , Pfeifer Aleksandra , Frydrych Zuzanna , Samborski Konrad , Kukulska Aleksandra , Krajewska Jolanta , Handkiewicz Junak Daria , Oczko Wojciechowska Małgorzata

Background: Total thyroidectomy and cervical lymph node resection is the standard treatment for MTC, as the cancer often occurs in both thyroid lobes and the incidence of lymph node metastasis reaches 80%, especially in patients with palpable tumor. However, previous analyses have included both hereditary and sporadic MTCs. In the ultrasound era, patients are referred for surgery earlier, often with not palpable MTCs, and the result of the germline RET oncogene mutation analys...