Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep356 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Plasma omentin-1 level does not change in the first trimester in women with gestational diabetes mellitus

Sancak Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

ea0020p195 | Endocrine tumours and neoplasia | ECE2009

Microalbuminuria and insulin resistance in nondiabetic acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Yavuz Dilek Gogas , Akalin Nefise Sema

Growth hormon (GH) counteracts the effects of insulin on glucose metabolism and GH excess may lead to insulin resistance (IR). Impaired glucose tolerance (IGT) and diabetes mellitus (DM) are frequently associated with acromegaly. Microalbuminuria (MAU) is a well established cardiovascular (CV) risk factor and a predictor of CV mortality in both diabetic and nondiabetic subjects.The aim of this preliminary study was to investigate the MAU levels as a mark...

ea0020p375 | Diabetes and Cardiovascular | ECE2009

ECoRI polymorphism but not XBaI polymorphism of apolipoprotein B gene is associated with carotis intima media thickness in type 2 diabetic patients

Yuksel Meral , Sancak Seda , Yazici Dilek Dereli , Ozben Beste , Gogas-Yavuz Dilek , Akalin Nefise Sema

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p415 | (1) | ECE2007

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Yazici Dilek , Tarcin Ozlem , Ozben Beste , Toprak Ahmet , Deyneli Oguzhan , Sancak Seda , Yavuz Dilek , Akalin Sema

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

ea0032p919 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Transsphenoidal surgery, gamma-knife surgery and diabetes are the factors affecting the quality of life in acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Temizkan Sule , Yavuz Dilek Gogas , Akalin N. Sema

Generously supported by IPSEN)-->Acromegaly is a chronic disease with an important impact on patients, health-related quality of life (HRQoL). Acromegaly quality of life questionnaire (AcroQoL) is a disease-generated QoL questionnaire comprising 22 questions each having five possible responses scored 1–5, the maximum score of 110 reflecting best possible QOL, and quoted as a percentage. The 22 items break down into two categorie...

ea0022p410 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Evaluation of respiratory function in acromegalic patient

Serap Yalin Ayse , Sancak Seda , Temizkan Sule , Gunes Mutlu , Deyneli Oguzhan , Yavuz Dilek , Karakurt Sait , Sema Akalin Nefise

Acromegaly alters elasticity, structure and function of the respiratory system and respiratory disorders constitute 25% of all deaths recorded in acromegalic patients. Respiratory mortality is three fold higher than in normal subjects. However, respiratory dysfunction in acromegaly has seldom been investigated.We aimed to evaluate the extent of pulmonary dysfunction in acromegalic patients with respiratory function tests (RFT). Sixty one acromegalic pati...

ea0020p564 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Carotid intima media thickness and other cardiovascular risk factors in acromegalic patients

Sancak Seda , Yalin Ayse Serap , Ozben Beste , Deyneli Oguzhan , Gunes Mutlu , Yavuz Dilek Gogas , Akalin Nefise Sema

Cardiovascular diasease (CV) is the leading cause of mortality in acromegalic patients. Although acromegalic cardiomyopathy has been extensively investigated, there is a lack of data about atherosclerosis in acromegaly.We aimed to the evaluate the extent of carotid atherosclerosis with various CV biomarkers in acromegaly. Sixty-one acromegalic patients and 21 age and sex matched healthy controls were included. We measured carotid intima media thickness (...

ea0014p275 | (1) | ECE2007

Effect of vitamin D replacement on endothelial function and oxidative stress in vitamin D deficient subjects

Tarcin Ozlem , Yavuz Dilek , Toprak Ahmet , Telli Ahu , Yuksel Meral , Yazici Dilek , Sancak Seda , Deyneli Oguzhan , Haklar Goncagul , Akalin Sema

Introduction: Vitamin D (Vit D) receptors have been shown in extra skeletal tissues. Vit D deficiency plays a role in the development of many malignant, chronic inflammatory, autoimmune and metabolic diseases. Our aim was to evaluate the effect of Vit D replacement therapy on insulin sensitivity, endothelial function and oxidative stress in Vit D deficient subjects.Material-method: Serum 25(OH) D levels of 74 volunteer-healthy subjects (22.7±2.7) we...

ea0014p337 | (1) | ECE2007

The relationship of epicardial fat thickness with carotid intima media thickness and endothelial function in subclinical and overt hypothyroidism

Yazici Dilek , Aydin Hasan , Özben Beste , Toprak Ahmet , Yavuz Dilek , Tarcin Ozlem , Sancak Seda , Deyneli Oguzhan , Akalin Sema

Hypothyroidism is associated with increased cardiovascular mortality. Epicardial fat thickness (EFT) has been found to be correlated with visceral fat accumulation and is thought to be a novel cardiovascular risk factor. The aim of this study was to determine EFT and its relationship with carotid intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in subclinical and overt hypothyroid patients.Ten patients with overt (Group H) (42.2±15...