Searchable abstracts of presentations at key conferences in endocrinology

ea0026s16.1 | TSH Receptor and thyroid disorders | ECE2011

TSH-receptor antibodies

Sanders J

TSHR autoantibodies with stimulating (agonist) activity cause the hyperthyroidism of GravesÂ’ disease, while the rarer blocking (antagonist) type TSHR autoantibodies are responsible for hypothyroidism in some patients. We have isolated four human monoclonal autoantibodies (MAbs) which bind the TSHR with high affinity. Two antibodies, M22 and K1-18 have potent thyroid stimulating activity, one MAb K1-70 has strong antagonist (blocking) activity and the fourth MAb 5C9 has st...

ea0003p154 | Genetics | BES2002

The angiotensin II response to an acute exercise stimulus and the angiotensin converting enzyme (ACE) genotype

Woods D , Jones A , Sanders J , Hurel S , Jamshidi Y , Hawe E , Goldstone J , Gohlke P , Humphries S , Montgomery H

The ACE I/D polymorphism is associated with resting ACE activity such that DD>ID>II. The D allele is strongly associated with increased exercise-induced left ventricular hypertrophy (LVH) and cardiovascular risk.Objective: Examine the relation between ACE genotype, exercise, circulating ACE and angiotensin II.Ethical approval was obtained and 17 (9DD, 8II) healthy, male (22.9+/-1.9 years, 178.6+/-2.8cm, 71.9+/-2.2kg) Caucasi...