Searchable abstracts of presentations at key conferences in endocrinology

ea0020p336 | Diabetes and Cardiovascular | ECE2009

Comparative molecular analysis of TRAIL ligand and receptor expression profiles in cyclophosphamide versus streptozotocin-induced diabetes in non-obese diabetic (NOD) mice

Kahraman Sevim , Dirice Ercument , Elpek Ozlem , Balci Mustafa Kemal , Omer Abdulkadir , Sanlioglu Salih , Sanlioglu Ahter

Background: NOD mice are the most frequently preferred animal models in type 1 diabetes (T1D) research. They develop spontaneous disease in 24 to 30 months. T1D can also chemically be induced in NOD mice for a faster disease progression. Two commonly used diabetes-inducing agents are Streptozotocin (STZ), which destructs pancreatic beta cells mainly through DNA fragmentation, and Cyclophosphamide (CY), which acts on suppressor T cells. TNF-Related Apoptosis-Inducing Ligand (TR...

ea0020oc2.1 | Diabetes & Obesity | ECE2009

ESE Young Investigator Award

Dirice Ercument , Sanlioglu Ahter Dilsad , Kahraman Sevim , Omer Abdulkadir , Balci Mustafa Kemal , Griffith Thomas S , Sanlioglu Salih

Background: Because type 1 diabetes (T1D) results from the T cell-mediated destruction of the insulin-producing pancreatic beta cells, the depletion of the autoreactive T cells via apoptosis represents a viable strategy for the prevention of autoimmune diabetes. The functional role TNF Related Apoptosis Inducing Ligand (TRAIL), a novel member of TNF superfamily, in autoimmune diabetes remains unknown. To understand this, TRAIL function was counteracted by an injection of solub...