Searchable abstracts of presentations at key conferences in endocrinology

ea0028p150 | Neoplasia, cancer and late effects | SFEBES2012

Extra corporeal radiotherapy – A novel therapy for Metastatic Malignant Paraganglioma

Santhakumar Anjali , Ball Steve

A 44 year old lady presented with weight loss to the gastroenterologists and a CT abdomen done picked up a mass below the pancreas. She underwent a percutaneous biopsy of this mass and the histology revealed a paraganglioma. She was referred to the endocrinology team. Subsequent questioning revealed coexistent symptoms of cataecholamine excess and plasma metanephrines of 4825 pmol/l and plasma normetanephrines of 166 pmol/L gave biochemical confirmation. MIBG scan showed a dir...

ea0028p292 | Reproduction | SFEBES2012

Periodic exposure to exogenous testosterone is required to maintain long-term integrity of the GnRH pulse-generator in a male with atypical Kallmann syndrome

Santhakumar Anjali , Quinton Richard

Kallmann syndrome is a treatable form of male infertility caused by a congenital defect in the secretion or action of gonadotropin releasing hormone (GnRH). It can permanently remit in around 10% of male cases. We report a patient with atypical KallmanÂ’s syndrome who requires intermittent testosterone replacement to sustain activity of his gonadotrophic axis A 55 year old male presented with erectile dysfunction and decreased libido. He reported normal puberty, with no hi...

ea0065p80 | Bone and calcium | SFEBES2019

Assessing the use of Cinacalcet for conservative management of primary hyperparathyroidism in a regional district general hospital

Kelly Neil Patrick , Santhakumar Anjali

Background: The treatment of choice for symptomatic primary hyperparathyroidism (PHPT) is surgery, however in many cases patient choice or medical comorbidities preclude this treatment modality.Aim: This audit examines the use of cinacalcet in management of primary hyperparathyroidism in a district general hospital to determine if it is in accordance with the National institute for health and care excellence (NICE) guidance (May 2019).<p class="abste...

ea0031p230 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Obesity-related hypogonadotrophic hypogonadism: recovery of normal pituitary–gonadal axis function following bariatric surgery

Santhakumar Anjali , Wahid Shaz , Quinton Richard

Background: Functional hypogonadotrophic hypogonadism (FHH) occurs in the context of any chronic disease including obese patients with type 2 diabetes (T2DM) and/or metabolic syndrome. FHH is reversible with resolution of the underlying disease process. Reported benefits of bariatric surgery include improvements in lipid profile, blood pressure and resolution of T2DM. Here we report reversal of FHH and T2DM with bariatric surgery-associated weight loss.C...

ea0031p310 | Pituitary | SFEBES2013

Pubertal induction in males with hypogonadotropic hypogonadism using long-acting intramuscular testosterone undecanoate 1g depot (Nebido)

Santhakumar Anjali , Miller Margaret , Quinton Richard

Background: Hypogonadotropic hypogonadism in apubertal males is commonly due to constitutional delay; permanent gonadotropin deficiency becomes more likely with older age at presentation, cryptorchidism and non-reproductive defect, e.g. anosmia. All forms of testosterone induce pubertal development, though short-acting IM preparations are associated with extraphysiological excursions of serum testosterone and are increasingly unavailable. Long-acting testosterone undecanoate I...

ea0025p182 | Endocrine tumours and neoplasia | SFEBES2011

A rare case of calcitonin and carcinoembryonic antigen negative medullary thyroid cancer

Santhakumar Anjali , Aspinall Sebastien , Woods David

Background: Routine measurements of serum calcitonin levels are considered an integral part of the diagnostic evaluation of medullary thyroid cancer (MTC). We report a rare case of calcitonin and carcinoembryonic antigen (CEA) negative MTC.Case presentation: A 63-year-old retired plasterer attending a well mans clinic was referred to the endocrinology service with elevated calcium (2.75 mmol/dl). Systemic examination was unremarkable and there was no end...

ea0021p246 | Pituitary | SFEBES2009

Management of diabetes insipidus during pregnancy

Munir Atif , Santhakumar Anjali , Conolly Vincent

Introduction: Diabetes insipidus can complicate up to 1 in 30 000 pregnancies and has a variety of causes, some that predate the pregnancy and others that begin during gestation. In addition, women can experience diabetes insipidus de novo in pregnancy through the actions of placental vasopressinase, which causes accelerated degradation of vasopressin. This form of diabetes insipidus may be associated with increased complications of pregnancy, including pre-eclampsia. M...

ea0025p86 | Clinical biochemistry | SFEBES2011

Calcitonin negative medullary thyroid cancer

Woods David , Santhakumar Anjali , Johnson Sara , Aspinall Seb

Medullary thyroid cancers (MTC) account for about 5% of thyroid cancers. The biochemical hallmark of MTC is the secretion of calcitonin (CT). CT levels are both a key feature of pre-operative diagnosis and post-operative follow up. CT screening in a cohort of over 10 000 patients with thyroid nodular disease has demonstrated that a positive CT test has a higher diagnostic sensitivity and specificity for MTC than fine needle aspiration (FNA). They may also secrete carcinoembryo...

ea0021p334 | Steroids | SFEBES2009

A rare cause of massive bilateral adrenal enlargement complicating management of congenital adrenal hyperplasia

Nag Sath , Munir Atif , Ullah Arif , Santhakumar Anjali

A 33-year-old lady presented to the surgeons with history of abdominal pain. CT scan abdomen done revealed massive adrenal enlargements reported as adrenal myelolipomas (left gland measuring 8.0×10.9×11.8 cm and multifocal lesions on the right with the larger one measuring 5.2×4.3×3.6 cm). She was referred to the endocrinology team where further history was elicited. She had been diagnosed as a child to have congenital adrenal hyperplasia (CAH) but was lost...

ea0021p401 | Thyroid | SFEBES2009

Management and follow up of post-operative hypocalcemia after thyroidectomy: a pilot study

Santhakumar Anjali , Munir Atif , Durning Pat , Nag Sath

Background: Although hypocalcemia is common post thyroidectomy, no national guidelines pertain to its management.Long-term treatment with calcium and vitamin D replacement predispose patients to nephrocalcinosis and should be avoided in the absence of a clear indication.Aim: To identify the incidence and management of post-operative hypocalcemia following thyroidectomy in a UK teaching hospital with view to formulating management g...