Searchable abstracts of presentations at key conferences in endocrinology

ea0027p68 | (1) | BSPED2011

Survey of management of diabetes in schools

Saraff Vrinda , McCrea Kathryn

Introduction: Type 1 diabetes mellitus is the third commonest chronic condition of childhood and unfortunately UK has one of the lowest percentages of children attaining good diabetes control in Europe. Department of Health has outlined recommendations to improve management of diabetes in schools and provide children with the necessary support required to achieve their maximum potential.Objective: To evaluate the provisions available in Shropshire and Po...

ea0036oc3.8 | Oral Communications 3 | BSPED2014

Trends in off-label prescription of GH: results from the National GH Audit

Saraff Vrinda , Shepherd Sheila , Shaw Nick

Introduction: National Institute of Health and Care Excellence (NICE) has provided guidance for the use of human recombinant GH in the treatment of growth failure in children. An ongoing National GH Audit was established in 2013 by BSPED to maintain a central database and gather information regarding trends in prescribing and facilitate future long-term follow up. This part of the audit looked at the trends of off label prescribing of GH.Method: Data wer...

ea0085oc5.6 | Oral Communications 5 | BSPED2022

Prevalence of overweight and obesity in children with bone fragility and its correlation with disease severity and fracture rate

Anilkumar Anjitha , Crabtree Nicola , Saraff Vrinda , Nadar Ruchi , Uday Suma

Aims: To examine, in children with Osteogenesis Imperfecta (OI): the prevalence of overweight and obesity, longitudinal trends in body mass index (BMI) z-scores and total body fat percentage (TBF) assessed on dual-energy X-ray absorptiometry (DXA) scans, correlation between BMI and TBF and fractures and BMI z-score.Methods: Retrospective cross-sectional and longitudinal analysis of children with OI, with minimum 5 years data on DXA scans, at a single nat...

ea0045p67 | Pituitary and growth | BSPED2016

Trends in growth hormone prescription in the UK: Results from the 3 year National Growth Hormone Audit

Saraff Vrinda , Shepherd Sheila , Patel Leena , Shaw Nick

Introduction: The National Growth Hormone (GH) audit was initiated in 2013 with funding from BSPED, to establish the ongoing trends in GH prescriptions in the UK and facilitate future long term follow up studies through a central database. Here we have studied the trends in GH prescribing and the indications for treatment from 2013 to 2015.Method: We examined data collected on a quarterly basis from centres across the UK on subjects less than 16 years of...

ea0078p57 | Pituitary and Growth | BSPED2021

Rapid-onset obesity, hypothalamic and autonomic dysregulation with neuroendocrine tumours: Can this be ROHHADNET?

Nadar Ruchi , Sakremath Rajesh , Kirk Jeremy , Randell Tabitha , Jenkinson Helen , Woodman Helen , Saraff Vrinda , Mohamed Zainaba

Introduction: ROHHADNET is a rare syndrome characterized by rapid onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumours. Although obesity is the first recognisable feature, there is variable onset of other features, resulting in delayed or missed diagnosis, potentially leading to fatal consequences. We describe two cases with features of ROHHADNET, who had high heterogeneity in clinical spectrum. Cas...

ea0051oc4.2 | Oral Communications 4 | BSPED2017

Cumulative radiation exposure from imaging and associated lifetime cancer risk in children with osteogenesis imperfecta

Thorby-Lister Amy , Hogler Wolfgang , Hodgson Kirsten , Crabtree Nicola , Shaw Nick , Saraff Vrinda

Background and objectives: Children with Osteogenesis Imperfecta (OI) require frequent imaging for fractures and surveillance of bone mineral density. Radiation exposure in childhood carries the highest risk of cancer. Here, we estimate the cumulative effective radiation dose (E) and lifetime cancer risk (LAR) from imaging in children with OI. We also explore the hypothesis that the rate of fracture positive imaging for investigation of injuries is related to family history of...

ea0058oc7.5 | Oral Communications 7 | BSPED2018

Diabetes control is worse in children and young people with type 1 diabetes requiring interpreter support

Idkowiak Jan , Elhag Sabba , Saraff Vrinda , Dias Renuka , Barrett Timothy , Kershaw Melanie , Krone Ruth

Introduction: Language barriers can pose a significant barrier to successful education of children and young people (CYP) with type 1 diabetes (T1DM) and their families, potentially influencing their glycaemic control.Methods: Retrospective analysis from diagnosis to 18 months post diagnosis of glycaemic control in 41 CYP with T1DM requiring interpreter support (INT) under care of our diabetes centre based within a multi-ethnic community. Median HbA1c at...

ea0095oc6.2 | Oral Communications 6 | BSPED2023

Children with hypophosphatasia treated with asfotase alfa: analysis from the UK Patients Cohort

Padidela Raja , Bishop Nick , Arundel Paul , Fang Shona , Zygouras Alexandros , Mughal Zulf , Shaw Nick , Saraff Vrinda

Objective: To describe outcomes among children with hypophosphatasia (HPP) receiving asfotase alfa.Methods: This prospective, real-world study used data from all children with HPP receiving asfotase alfa in the UK Managed Access Agreement (MAA) to assess functional, health-related quality-of-life, and safety outcomes. Visits occurred at MAA enrolment, 3 and 6 months after enrolment, and every 6 months thereafter. Assessm...

ea0066p36 | Diabetes 3 | BSPED2019

Using NPDA data for quality improvement: dedicated annual review clinics are effective in increasing completion rates of health care processes

Elbashir Nihal , Kershaw Melanie , Dias Renuka , Mohamed Zainab , Idkowiak Jan , Saraff Vrinda , Uday Suma , Barrett Tim , Krone Ruth

Introduction: NICE recommends specific annual health checks for children and young people (CYP) with diabetes aged 12 years and over to check for health of feet, kidneys, thyroid and eyes in addition to BP, BMI and HbA1c. Historically, we included annual review care processes into regular diabetes multi-disciplinary clinics. In 2017, our service was identified as negative outlier in the National Paediatric Diabetes Audit for completion of health care processes. In particular, ...

ea0058p050 | Diabetes | BSPED2018

A survey of the use of medical identification in children and young people with diabetes at a large children’s hospital

Yorke Jessica , Drummond Lesley , Collins Louise , Sands Donna , Krone Ruth , Saraff Vrinda , Dias Renuka , Barrett Timothy , Kershaw Melanie

Objectives: Children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM) are at risk of acute clinical emergencies. Wearing medical identification (ID) is recommended by the National Institute for Clinical excellence (NICE). Information on adherence to this recommendation in CYP with T1DM is scarce. This study aimed to assess parent and CYP’s knowledge of the recommendation, to explore adherence and barriers to carrying ID and understand preferred forms of ID....