Searchable abstracts of presentations at key conferences in endocrinology

ea0014p346 | (1) | ECE2007

Genotype/phenotype relation for toxic thyroid nodules with or without TSH receptor mutations

Gozu Hulya , Mueller Sandra , Bircan Rifat , Krohn Knut , Sargin Mehmet , Sargin Haluk , Gezen Cem , Erginer Turgay , Karadayi Nimet , Paschke Ralf

Constitutive activation of the cAMP pathway by activating TSHR mutation stimulates both thyrocyte proliferation and function. Thus they lead to formation of toxic thyroid nodules (TTNs) and ultimately hyperthyroidism. The in vitro activity of the various TSH-receptor mutation varies from 2–7 fold cAMP increase over the wild type TSH receptor. One previous study invrestigated a possible genotype to phenotype relation in TTNs with somatic TSHR mutation with a negativ...

ea0014p483 | (1) | ECE2007

Myasthenia gravis and autoimmune Addison’s disease in a patient with thymoma

Seker Mesut , Iliksu Gozu Hulya , Sonmez Berkant , Yavuz Fatih , Salepci Taflan , Orbay Ekrem , Sargin Mehmet , Sargin Haluk , Gumus Mahmut , Turk Boru Ulku , Yaylaci Mustafa , Yayla Ali

The association of thymoma with myasthenia gravis is well known, however association of these two syndromes (Thymoma+Myasthenia gravis) with Addison’s disease is very rare. In here we report myasthenia gravis and autoimmune Addison’s disease in a patient with thymoma.A 32-year-old man was admitted to our hospital with symptoms of weakness, anorexia, nausea, vomiting, pigmentation of skin and mucous membranes for 2 years. He had undergone to the...

ea0037ep356 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Plasma omentin-1 level does not change in the first trimester in women with gestational diabetes mellitus

Sancak Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

ea0037ep358 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Serum irisin level increases throughout the gestational period and it does not play role in development of gestational diabetes mellitus

Seda Seda , Aydin Hasan , Sargin Mehmet , Orcun Asuman , Ozdemir Ali , Celik Ayhan , Aslan Gulgun

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

ea0037ep593 | Obesity and cardiovascular endocrinology | ECE2015

Is there a relationship between parathyroid hormone and obesity-linked disorders

Temizkan Sule , Demir Sevin , Aydin Kadriye , Ozturk Hilal Toplu , Ozderya Aysenur , Sargin Mehmet

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar ...

ea0011p824 | Thyroid | ECE2006

Clinical characterisation and genetic analysis of a large euthyroid family with TSH-receptor germline mutation (N372T) and a hyperthyroid index patient with an additional somatic tsh-receptor mutation (S281N) on the second TSH-receptor allele

Gozu Hulya Iliksu , Bircan Rifat , Krohn Knut , Müller Sandra , Yavuzer Dilek , Ekinci Gazenf , Sargin Haluk , Sargin Mehmet , Orbay Ekrem , Cirakoglu Beyazi , Paschke Ralf

Objective: 21 different activating germline mutations have been identified up to date. We describe a large euthyroid family with a new TSH-receptor(TSHR) germline mutation where the hyperthyroid index patient also carries a somatic TSHR mutation.Method: Mutation analysis of the exon 9 and 10 of the TSHR gene from the peripheral blood samples of the members of this family and toxic thyroid nodules of the index patient were performed by denaturing gradient...

ea0011p836 | Thyroid | ECE2006

Prevalence of somatic TSHR and GS alpha mutations in toxic thyroid nodules (TTNS) in endemic and nonendemic goiter areas of turkey

Gozu Hulya Iliksu , Bircan Rifat , Krohn Knut , Müller Sandra , Vural Selaha , Gezen Cem , Sargin Haluk , Sargin Mehmet , Çirakoglu Beyazi , Paschke Ralf

Objective: Differences in iodine intake could account for the variable prevalences reported for somatic TSHR and Gs alpha mutations in TTNs. However, this question has never been setteled, since no study has yet determined the TSHR mutation prevalence in TTNs in regions with and without iodine deficiency in the same population. Therefore we studied the prevalence of somatic TSHR mutations in TTNs by investigating TTNs from patients who lived in endemic and nonendemic goiter re...