Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep766 | Pituitary and Neuroendocrinology | ECE2022

A paradox in clinical practice: the case of a hidden tubercoloma

Parolin Matteo , Parisotto Matteo , uliana ambra , Sartorato Paola , Menis Ernesto De

Introduction: A potential cause of panhypopituitarism could be cerebral tubercular lesions, that are often misdiagnosed. Hormonal effects could be related directly to primary tubercular lesions, or after starting antitubercular therapy. Paradoxical reaction (PR) in tuberculosis is defined as clinical or radiological worsening of pre-existing tuberculous lesions or development of new lesions after beginning an appropriate antitubercular therapy (ATT). It has been suggested that...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...

ea0016p586 | Paediatric endocrinology | ECE2008

The role of desmopressin test in the diagnosis of young patients with Cushing's disease

Sartorato Paola , Zulian Elisa , Testa Miranda , Albiger Nora , Brunner Marie Eve , De Marchi Cecilia , Ferasin Sergio , Mantero Franco , Scaroni Carla

In the diagnosis of CushingÂ’s disease (CD) desmopressin (dDAVP) stimulation test may be a convenient and more readily available alternative to CRH test; however the sensibility and specificity of ACTH response to dDAVP test has been reported in adult patients inferior to CRH test. In childhood patients with CD there are no data for the use of dDAVP test in this clinical setting. We studied 9 patients ranging in age from 11 to 19 years (7 females and 2 males) with a suspec...

ea0081p396 | Pituitary and Neuroendocrinology | ECE2022

Precision medicine: new perspectives for the treatment of GH-secreting tumors - the miss study

Maria Berton Alessandro , Prencipe Nunzia , Bertero Luca , Corsico Marina , Cuboni Daniela , Baldi Marco , Bima Chiara , Bianchi Antonio , Mantovani Giovanna , Ferrau Francesco , SARTORATO PAOLA , Gagliardi Irene , Grottoli Silvia

Introduction: First-generation SRL (fg-SRL) represent the treatment of choice in acromegaly patients with post-neurosurgical adenomatous remnant and GH-hypersecretion. Anyway, approximately 60% of patients do not achieve adequate disease control. The main predictors of resistance include male sex, young age, invasiveness of the lesion and its hyperintensity on T2-weighted MRI scans; but also, SSTR2 expression, the cytokeratin pattern, Ki-67 and the presence of AIP gene mutatio...