Searchable abstracts of presentations at key conferences in endocrinology

ea0014p72 | (1) | ECE2007

Polymorphisms of von Willebrand factor gene promoter modulate the corticosteroid-mediated increase of VWF levels in Cushing’s syndrome.

Daidone Viviana , Sartorello Francesca , Albiger Nora , Mantero Franco , Pagnan Antonio , Casonato Alessandra , Scaroni Carla

Cushing’s syndrome (CS) is associated with hypercoagulable state, mainly dependent on corticosteroid-induced increase of von Willebrand factor (VWF) levels, even though this does not affects all patients. In normals plasma VWF levels are genetically determined by ABO blood groups and polymorphisms G/C −1793, C/T −1234, A/G −1185, G/A −1050 of VWF promoter. These SNPs segregate as haplotype 1 (G/C/A/G) and haplotype 2 (C/T/G/A) with genotype 1/1 (GG...