Searchable abstracts of presentations at key conferences in endocrinology

ea0016p389 | Neuroendocrinology | ECE2008

Body fat excess and GH-stimulated levels in adult patients with Prader–Willi syndrome

Grugni Graziano , Crino Antonino , Bertocco Paride , Sartorio Alessandro , Marzullo Paolo

The GH response to standard provocative tests is significantly lower in adult patients with Prader–Willi syndrome (PWS) than obese controls with similar body mass index (BMI). Nevertheless, BMI is an inadequate measure of body composition in PWS, because PWS harbour a higher fat mass than simple obesity, under the same degree of weight excess. This study evaluated either the GH response to combined GHRH+arginine administration and the fat body mass, by dual energy X-ray a...

ea0035p853 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Assessment of the hypothalamus–pituitary–adrenal axis with different corticotropin tests in adult patients with Prader–Willi syndrome

Grugni Graziano , Corrias Andrea , Sartorio Alessandro , Beccaria Luciano , Bocchini Sarah , Di Candia Stefania , Fintini Danilo , Iughetti Lorenzo , Mussa Alessandro , Ragusa Letizia , Gargantini Luigi , Salvatoni Alessandro , Delvecchio Maurizio , Chiumello Giuseppe , Crino Antonino

Introduction: Hypothalamic–pituitary anomalies are well proven in Prader–Willi syndrome (PWS). In this context, it has been previously reported that central adrenal insufficiency (CAI) may be part of the PWS phenotype. However, the diagnostics of CAI is critical and debated, due to the lack of fully reliable tests. Several studies have looked at the clinical usefulness of the low dose (1 μg) short Synacthen test (LDSST) compared to the conventional dose (250 &#9...

ea0014oc1.1 | Thyroid clinical | ECE2007

Prevalence of inactivating TSH receptor (TSHR) mutations in a large series of pediatric subjects with non-autoimmune mild hyper-thyrotropinemia (hyperTSH)

Cordella Daniela , Marco Alessandro De , Calebiro Davide , Filippis Tiziana de , Radetti Giorgio , Weber Giovanna , Vigone Maria Cristina , Cappa Marco , Sartorio Alessandro , Busnelli Marta , Bonomi Marco , Chini Bice , Beck-Peccoz Paolo , Persani Luca

Mild hypothyroidism is a heterogeneous and frequent disorder in the general population that is due to autoimmune disease in most of the cases. TSH resistance is considered a rare genetic disease due to germline loss-of-function TSHR mutations. However, TSHR mutations have been mainly searched in patients with large TSH elevations and their actual prevalence among patients with mild TSH elevations (as those found in mild hypothyroidism) is so far unknown. In this study, we eval...