Searchable abstracts of presentations at key conferences in endocrinology

ea0090oc6.6 | Oral Communications 6: Endocrine-related Cancer | ECE2023

Cellular landscape of adrenocortical carcinomas determined by molecular profiling of primary, recurrent and metastatic tumour samples at single-nuclei resolution.

Altieri Barbara , S. Tourigny David , Secener Ali Kerim , Sbiera Silviu , Arampatzi Panagiota , Sauer Sascha , Fassnacht Martin , Ronchi Cristina

Background: Molecular mechanisms of malignant adrenocortical tumorigenesis remain elusive despite previous comprehensive genomic studies. Nonetheless, cellular heterogeneity of primary, recurrent and metastatic adrenocortical carcinoma (ACC) haven’t been fully investigated.Aim: To characterize the molecular profile of different cell subtypes in primary, recurrent and metastatic ACC by single-nuclei RNA sequencing (snRNA-Seq), using adult human norma...

ea0081yi2 | Young Investigator Awards | ECE2022

Single-nuclei transcriptome of adult human adrenal glands reveals novel insights into molecular mechanisms intrinsic to adrenocortical tumourigenesis and cortisol secretion

Altieri Barbara , Secener Ali Kerim , Sai Somesh , Fischer Cornelius , Sbiera Silviu , Arampatzi Panagiota , Vitcetz Sarah , Braeuning Caroline , Sauer Sascha , Fassnacht Martin , Ronchi Cristina

Background: Molecular mechanisms underlying the pathogenesis of adrenocortical adenomas (ACAs) and autonomous cortisol secretion remains frequently unexplained despite previous comprehensive genomics studies.Aim: To gain novel insights into molecular pathogenesis of adrenocortical tumours by investigating transcriptome profiles of ACAs at single-nuclei resolution (snRNA-Seq), using adult human normal adrenal glands (NAGs) as reference.<p class="abste...

ea0070yi3 | Young Investigators | ECE2020

RNA-sequencing of adrenocortical tumors reveals novel pathogenetic insights

Di Dalmazi Guido , Altieri Barbara , Scholz Claus , Sbiera Silviu , Luconi Michaela , Waldmann Jens , Kastelan Darko , Ceccato Filippo , Chiodini Iacopo , Arnaldi Giorgio , Osswald Andrea , Reincke Martin , Beuschlein Felix , Sauer Sascha , Fassnacht Martin , Appenzeller Silke , Ronchi Cristina

Background: Genetic alterations underlying the pathogenesis of autonomous cortisol secretion and early adrenocortical tumorigenesis have been identified in 40% of adrenocortical tumors (ACT). Nonetheless, the molecular events leading to development of ACT and steroid secretion remain obscure for a large proportion of patients.Aim: Aims of our study were to investigate the relationship between transcriptome profile and genetic background in a large series...