Searchable abstracts of presentations at key conferences in endocrinology

ea0077lb47 | Late Breaking | SFEBES2021

Evening Chronotype and type 2 diabetes: what link in menopause?

Barrea Luigi , Vetrani Claudia , Verde Ludovica , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light-dark cycle.The morning chronotype (MC) prefers activities earlier in the day, while the evening chronotype (EC) perform its main activity late in the day. Intermediate chronotype (IC) is in an intermediate position between MC and EC. EC as well as menopause have been associated to an increased risk of cardiometabolic diseases (CMD) in ob...

ea0081p97 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Chronotype: a tool to screen eating habits in Polycystic Ovary Syndrome?

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Background: Polycystic Ovary syndrome (PCOS) is the most common endocrine disorders in women of reproductive age whose lifestyle approach is an essential part of the treatment. Recently chronotype, i.e. a trait that determines individual’s circadian preference in behavioral and biological rhythms, has been reported to play a role in determining nutrition preferences and the risk of developing chronic diseases. Thus, the aim of the study was to investigate if chronotype ca...

ea0081p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

VLCKD: a real time safety study in obesity

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Marino Francesca , Aprano Sara , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out in normal weight subjects following ketogenic diet for other purposes than obesity. Thus, the aims of the study were: 1) to investigate the safety of VLCKD in subjects with obesity; 2) if VLCKD-related side effects could have an impact on its efficacy. In this prospectiv...

ea0020p561 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Glucose tolerance and somatostatin analogues treatment in acromegaly: a 12 month open, prospective study

Colao Annamaria , Auriemma Renata S , Savastano Silvia , Galdiero Mariano , Grasso Ludovica FS , Lombardi Gaetano , Pivonello Rosario

Objective: The impact of first-line somatostatin analogues (SSA) on glucose tolerance in acromegaly was investigated during a 10 year period.Patients: One hundred and twelve patients treated with depot SSA.Outcome measures: Primary outcome measures were fasting glucose levels. Data were analyzed according with baseline glucose tolerance and disease control.Results after 12 months SSA treatment: In the 63 pati...

ea0081p90 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evening chronotype is associated with hormonal and metabolic disorders in Polycystic Ovary Syndrome

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Docimo Annamaria , De Alteriis Giulia , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Objective: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder. Recently in the context of obesity, which often coexists with PCOS, it has been highlighted the role of chronotype as risk factor for obesity-related cardiometabolic complications. Given the importance of chronotype categories in the context of metabolic diseases and being PCOS characterized by metabolic derangements, we aimed to investigate the prevalence of chronotype categories in wome...

ea0070aep718 | Pituitary and Neuroendocrinology | ECE2020

Evaluation of early predictors of metabolic syndrome in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET)

Bottiglieri Filomena , Modica Roberta , Barrea Luigi , de Cicco Federica , Minotta Roberto , Muscogiuri Giovanna , Savastano Silvia , Faggiano Antongiulio , Colao Annamaria

Metabolic syndrome and obesity (MetS) are supposed to have a role in cancer but data analysing their association with GEP-NET are lacking. Aim of this study was to explore the association of early predictors of MetS with GEP-NET, usingas tools Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD)and Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction. A cross-sectional case-control observational study was conducted. VA...

ea0016p394 | Neuroendocrinology | ECE2008

Growth hormone (GH) treatment on atherosclerosis: results of a 5 years open, prospective, controlled study in male patients with severe GH deficiency

Colao Annamaria , Di Somma Carolina , Spiezia Stefano , Savastano Silvia , Rota Francesca , Savanelli Maria Cristina , D'Andrea Marianna , Lombardi Gaetano

Background: Severe GH deficiency (GHD) is associated with, increased cardiovascular (CV) risk and intima-media thickness (IMT) at major arteries.Objective: To investigate the long-term (5-years) effects of GH replacement on insulin resistance (IR) syndrome (IRS) (at least two of: triglycerides levels ≥1.7 mmol/l, HDL-cholesterol levels ≤1.0 mmol/l, blood pressure above 130/85 mmHg, fasting glucose 6.1–7 or 2 h after glucose 7.7–11.1...

ea0063p36 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Vitamin D deficiency is a predictor marker of tumor aggressiveness in sporadic and MEN1-related well-differentiated, low-grade GEP-NET

Altieri Barbara , Barrea Luigi , Modica Roberta , Circelli Luisa , Bottiglieri Filomena , Cicco Federica De , Savarese Giovanni , Somma Carolina Di , Colao Annamaria , Savastano Silvia , Faggiano Antongiulio

Background: Vitamin D has several ‘noncalcemic’ implications, including effects on cell signaling and differentiation. Patients with gastroenteropancreatic (GEP) neuroendocrine tumors (NET) have an increased risk of vitamin D deficiency, due to the tumor itself, systemic therapies and abdominal surgery. However, data regarding vitamin D status are limited. Aim of this study was to evaluate 25-hydroxy-vitamin-D (25(OH)D) levels in GEP-NET patients and correlated them ...

ea0037gp.01.03 | Adrenal | ECE2015

Effect of the switch from conventional glucocorticoids to ‘dual release hydrocortisone' in adult patients with primary and secondary adrenal insufficiency: a 6-month multicentre study

Pivonello Rosario , Simeoli Chiara , Isidori Andrea M , Ciresi Alessandro , Savastano Silvia , Auriemma Renata S , Graziadio Chiara , Di Somma Carolina , Giordano Carla , Lenzi Andrea , Colao Annamaria

Adrenal insufficiency (AI) requires life-long glucocorticoid (GC) treatment, which is associated with an increased risk of metabolic syndrome (MS), probably due to cortisol overexposure for multiple drug daily doses, together with an impairment of quality of life (QoL). Moreover treatment compliance (TC) is reported to be suboptimal in AI patients. The current study aimed at investigating the impact of the switch from twice/thrice daily conventional GCs to once daily dual-rele...

ea0014p262 | (1) | ECE2007

Body composition and GH status in morbidly obese females before and after laparoscopic silicone adjustable-gastric banding

Savastano Silvia , Colao Annamaria , Rota Francesca , Vuolo Laura , Cristina Savanelli Maria , Cascella Teresa , Orio Francesco , Angrisani Luigi , Lombardi Gaetano , Di Somma Carolina

The GH/IGF-I axis function are reported to ameliorate after weight-loss. Bariatric surgery leads to a significant weight loss in morbidly obese patients. We investigated the relationships between GH/IGF-I axis and body composition in 20 morbidly obese females (BMI: 44.8±4.7; waist circumference (W) 119.5±7.2 cm, age 33.7±11.7 yrs) with a normal glucose tolerance, before and after laparoscopic silicone adjustable-gastric banding (LASGB). The GH axis was evaluated...