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ea0025p156 | Diabetes, metabolism and cardiovascular | SFEBES2011

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE^−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

Kipari Tiina , Man Tak-Yung , Hadoke Patrick , Savill John , Chapman Karen , Seckl Jonathan

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates glucocorticoids in intact cells, converting inert cortisone into active cortisol. We have previously shown attenuated atherosclerosis development, reduced plasma monocyte chemoattractant protein-1 (MCP-1) and reduced macrophage/T cell infiltration within atherosclerotic lesions in 11β-HSD1−/−×ApoE−/− double knock-out (DKO) mice fed western diet (WD)....

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ea0019oc9 | Neuroendocrine and Steroids | SFEBES2009

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

Yang Fu , Duffin Rodger , Brownstein David G , Coutinho Agnes , Rossi Adriano G , Savill John S , Seckl Jonathan R , Chapman Karen E

Glucocorticoids are potent anti-inflammatory agents. Endogenous glucocorticoid action is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) which interconverts active (cortisol, corticosterone) and intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone). 11β-HSD type 1 regenerates active glucocorticoids. 11β-HSD 1 highly expressed in the lung but its role is little explored.Immunohistochemical staining of mouse ...

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Endocrine Abstracts

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE^−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

BiosciAbstracts

Endocrine Abstracts

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

BiosciAbstracts

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE^−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat