Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc6.4 | Metabolism and cardiovascular | ECE2008

Lipolysis in subcutaneous tissue after intranasal administration of ACTH(4-10) is associated with an increased baroreceptor reflex sensitivity

Wellhoner Peter , Horster Ruth , Jacobs Friederike , Sayk Friedhelm , Heutling Dennis , Lehnert Hendrik , Dodt Christoph

The melanocortin system plays a significant role in the hypothalamic regulation of body weight and energy expenditure. Prolonged central administration of the melanocortin receptor 4 (MC-4) agonist ACTH(4-10) reduces body weight in animals and humans by increasing energy expenditure and by reducing food intake. The aim of this study was to investigate the effect of intranasally administered alpha-MSH on local lipolysis in subcutaneous adipose tissue and on sympathetic nerve ac...