Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp2 | Adrenal | ECE2016

Screening for a ten-gene panel in a group of 90 phaeochromocytomas

Sbardella Emilia , Cranston Treena , Mihai Radu , Grossman Ashley

Background: Several new gene mutations have been reported in recent years to be associated with a risk of familial phaeochromocytomas (PHAEOs). However, it is unclear as to whether extensive genetic testing is required in all patients (pts).Methods: Clinical data of consecutive patients operated for PHAEO over a decade in a tertiary referral centre were reviewed. Genetic screening was performed using a ten-gene panel: RET, VHL, SDHB, SDHD, SDHA, SDHC, SD...

ea0044p25 | Adrenal and Steroids | SFEBES2016

Random spot urinary metanephrines compared to 24-h collection in the diagnosis and follow up of phaeochromocytomas and paragangliomas: preliminary results

Sbardella Emilia , Isidori Andrea M , Shine Brian , Jafar-Mohammadi Bahram , Grossman Ashley B

Introduction: Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours with high morbidity. The majority are benign and surgically curable, but genetic testing suggests that many are associated with germline mutations, and careful long-term follow-up of patients and their family members is important. Regular biochemical screening with plasma or urinary metanephrines (uMetanephrines) is essential, but currently 24-h collections of uMetanephrines is cumbersome and inconven...

ea0044p113 | Diabetes and Cardiovascular | SFEBES2016

High risk populations: Attitudes to NAFLD among diabetologists

Marjot Thomas , Sbardella Emilia , Hazlehurst Jonathan , Moolla Ahmad , Cobbold Jeremy , Tomlinson Jeremy

Introduction: Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common conditions that regularly coexist and can act synergistically to drive adverse outcomes. The prevalence of NAFLD in T2DM is 70%, with 16% having evidence of advanced hepatic fibrosis.Aims: Our study therefore had two aims: Firstly, to define the attitudes and current clinical practice of diabetes specialists towards NAFLD across the UK and secondly, to implement...

ea0044p149 | Neuroendocrinology and pituitary | SFEBES2016

Pituitary stalk thickening: use of an innovative MRI analysis to guide clinical management

Sbardella Emilia , Joseph Robin N , Jafar-Mohammadi Bahram , Isidori Andrea M , Cudlip Simon , Grossman Ashley B

Context: Disease processes that affect the pituitary stalk are broad, ranging from indolent lesions requiring simple observation to severe lesions with significant implications. Diagnosis and management of these lesions remains unclear.Objective: The aim of this study was to assess the clinical presentation, biochemical and pathology characteristics of pituitary stalk thickening lesions and their association with specific MRI features in order to provide...

ea0063p453 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Risk factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a case-control study from NETTARE Unit

Feola Tiziana , Sesti Franz , Puliani Giulia , Sbardella Emilia , Cozzolino Alessia , Lenzi Andrea , Faggiano Antongiulio , Isidori Andrea M , Giannetta Elisa

Introduction: GEP-NENs represent a heterogeneous group of neoplasms with increasing incidence in the last years. Pathogenesis and risk factors of sporadic GEP-NENs are not clear and still debated. The aim of this study is to evaluate the main risk factors for sporadic GEP-NENs in patients followed by the NETTARE Unit (NeuroEndocrine TAsk force of of ‘Sapienza’ University of Rome).Methods: We performed a case-control study including 32 consecuti...

ea0049ep1050 | Pituitary - Clinical | ECE2017

Effects of somatostatin analogs on glucose metabolism in acromegalic patients: a meta-analysis of prospective interventional studies

Feola Tiziana , Cozzolino Alessia , Simonelli Ilaria , Sbardella Emilia , Puliani Giulia , Giannetta Elisa , Pasqualetti Patrizio , Lenzi Andrea , Isidori Andrea M

Introduction: Glucose metabolism impairment is a common complication of acromegaly. Somatostatin analogs (SSAs) are used as both first and second line treatment. The effect of SSAs on glucose metabolism in acromegaly is still debated.Aim: To address the following questions: 1) do SSAs affect glucose metabolism? 2) does the effect correlate with disease control? 3) do different SSAs – Lanreotide (LAN) and octreotide LAR (OCT) – affect metabolism...

ea0049ep1054 | Pituitary - Clinical | ECE2017

Quantitative analysis of the pituitary gland at magnetic resonance imaging in obese patients

Puliani Giulia , Lubrano Carla , Fiorelli Marco , Sbardella Emilia , Graziadio Chiara , Gianfrilli Daniele , Lenzi Andrea , Isidori Andrea M

Background: Hypothalamic-pituitary function and adipose tissue are deeply interconnected. Obesity has been linked to morpho-functional changes in several endocrine glands (thyroid, adrenal, gonads). No study has quantified the appearance of the pituitary gland in obese subjects.Aim: To measure pituitary signal intensity, homogeneity and texture of the pituitary gland at magnetic resonance (MR) in obese subjects free of focal pituitary disease.<p clas...

ea0037ep973 | Thyroid (non-cancer) | ECE2015

Morphological and functional alterations of thyroid gland during treatment with tyrosine kinase inhibitors in advanced renal cell carcinoma

Rizza Laura , Giannetta Elisa , Sbardella Emilia , Lauretta Rosa , Gianfrilli Daniele , Lenzi Andrea , Longo Flavia , Isidori Andrea M

Background: Sunitinib (SUN) is a novel oral multitarget tyrosine-kinase inhibitor (TKI) that has demonstrated its efficacy in the treatment of metastatic renal cell carcinoma (mRCC). The thyroid dysfunction is one of the most common side effects of SUN. The mechanisms inducing thyroid dysfunction are still poorly understood.Aim: Identify the incidence, severity, ultrasonographic changes and pattern of response of thyroid function tests during treatment w...

ea0070aep528 | Endocrine-related Cancer | ECE2020

Sarcopenia can predict response to therapy in NSCLC patients treated with PD-1 inhibitors: A longitudinal prospective study.

Tenuta Marta , Sbardella Emilia , Pandozzi Carla , Gelibter Alain J. , Sirgiovanni Grazia , Giannetta Elisa , Pozza Carlotta , Lenzi Andrea , Isidori Andrea

Introduction: Immune checkpoint inhibitors (ICI) show promising efficacy in the treatment of a wide range of advanced cancers, butlong-term response is currently limited to a subset of patients. Sarcopenia is a condition characterized by loss of skeletal muscle mass and decreased muscle function which occurs in approximately 50% of advanced cancer patients,related to malnutrition, inflammation, and treatments.Objective: The aim of this prospective o...

ea0075a10 | Adrenal gland | EYES2021

Impact of adrenalectomy on cardiovascular features in patients with adrenal incidentalomas and possible autonomous cortisol secretion: Results from ITACA study

Minnetti Marianna , Bonaventura Ilaria , Angelini Francesco , Sbardella Emilia , Pofi Riccardo , Cozzolino Alessia , Gianfrilli Daniele , Lenzi Andrea , Isidori Andrea M.

Background: Patients with adrenal incidentalomas and possible autonomous cortisol secretion (pACS) suffer from a high rate of cardiovascular events and mortality. We have previously showed that left ventricular mass index (LVMi) is higher in patients with pACS, compared with patients with non-functioning adenomas (NFA). To date, the management of pACS is still controversial, with a lack of consensus regarding the benefits of surgery.Objectives: This pros...