Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc10.6 | Obesity & metabolism | ECE2007

3-Iodothyronamine (T1AM) is a novel modulator of metabolic rate and glucose homeostasis

Grandy David K. , Suchland Katherine L. , Keck Thomas M. , Yan Feifei , Shyng Show-Ling , Scanlan Thomas S.

3-Iodothyronamine (T1AM) is a novel endogenous derivative of thyroid hormone (TH), recently described by Scanlan et al. (Nat. Med. 10: 638, 2004). In vitro, T1AM can stimulate the production of cAMP via activation of a heterologously expressed G protein-coupled receptor (GPCR) now referred to as trace amine-associated receptor 1 (TAAR1; Lindemann et al. Genomics 85: 372, 2005). In adult, unanesthetized C57Bl6/J mice, T1AM produces prof...