Searchable abstracts of presentations at key conferences in endocrinology

ea0063p735 | Pituitary and Neuroendocrinology 2 | ECE2019

The changing face of cushing disease in the 21st century: mood disorders and body image perception

Urbani Claudio , Lai Elisa , Ciapparelli Antonio , Alfi Gaspare , Mantuano Michele , Menicucci Danilo , Scattina Ilaria , Marconcini Giulia , Cappellani Daniele , Marcocci Claudio , Manetti Luca , Gemignani Angelo , Bogazzi Fausto

Introduction: CushingÂ’s Disease (CD) has been associated with the occurrence of psychopathologies, the most frequent of which are depression and anxiety. However, the extent of psychopathological disturbances of CD in the 21st century is elusive.Objectives: To explore psychopathologies and body image uneasiness (BIU) in untreated CD patients.Patients & methods: It was a prospective observational study enrolling 23 consecut...

ea0041ep863 | Pituitary - Basic | ECE2016

Polychlorinated biphenyls affect apoptosis of pituitary cells through extrinsic and intrinsic pathways

Raggi Francesco , Russo Dania , Urbani Claudio , Cappellani Daniele , Manetti Luca , Sardella Chiara , Lupi Isabella , Scattina Ilaria , Tomisti Luca , Marcocci Claudio , Martino Enio , Bogazzi Fausto

Introduction: Polychlorinated biphenyls (PCBs) are environmental pollutants that modulate endocrine functions, induce tumorigenesis, and regulate apoptosis in several tissues; however, their effects on the apoptosis of pituitary cells is unknown.The aim of this study was to evaluate the PCBs influence on the apoptosis of normal pituitary cells and elucidate the molecular mechanisms involved.Methods: Primary cell cultures from mouse...

ea0041ep883 | Pituitary - Clinical | ECE2016

Disease activity and lifestyle influence the occurrence of cardiovascular risk factors and cardiovascular events in acromegaly

Sardella Chiara , Cappellani Daniele , Urbani Claudio , Manetti Luca , Marconcini Giulia , Tomisti Luca , Lupi Isabella , Rossi Giuseppe , Scattina Ilaria , Lombardi Martina , Di Bello Vitantonio , Marcocci Claudio , Martino Enio , Bogazzi Fausto

Context: Acromegalic patients have a high-risk cardiovascular profile. However, the determinants of cardiovascular risk factors and major cardiovascular events (MACE), which may develop after diagnosis of acromegaly, are not fully understood.Objectives: To identify the predictors for systemic comorbidities and MACE, after diagnosis of disease. The role of therapy for acromegaly on the occurrence of such complications was also evaluated.<p class="abst...