Searchable abstracts of presentations at key conferences in endocrinology

ea0021s3.2 | Stem cells - therapeutic potential and endocrine applications | SFEBES2009

Pluripotent stem cells in the testis: restoring fertility

Schlatt Stefan

Spermatogonial stem cells open novel strategies for derivation of pluripotent cell lineages and fertility preservation in boys and men exposed to gonadotoxic therapies. The testicular stem cells are descendants of the primordial germ cells. They are the only germline cells remaining mitotically active in adulthood. Their highly specialized task is the preservation of DNA integrity in the germline. In contrast to all other stem cells they do not serve any beneficial functions f...

ea0016s25.2 | Stem cell and regeneration | ECE2008

Stem cells in the gonads: novel options for fertility preservation?

Schlatt Stefan

Male and female germline development during sexual differentiation differs significantly. While in the testicular microenvironment primordial germ cells differentiate into a stem cell, the spermatogonium, the female pathway leads to the establishment of a limited pool of oocytes arrested in prophase of meiosis. Recently, exciting research has improved the understanding of pathways involved in germ cell differentiation and maintenance of pluripotency. In vitro and in ...

ea0063gp68 | Reproductive Axis | ECE2019

DHT, rather than free testosterone, influences symptoms of aging in eugonadal men

Sansone Andrea , Kliesch Sabine , Tuttelmann Frank , Dugas Martin , Isidori Andrea M. , Schlatt Stefan , Zitzmann Michael

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

ea0022p742 | Steroid metabolism & action | ECE2010

Tissue expression of the CYP19A1 gene and aromatase protein in male cynomolgus monkeys (Macaca fascicularis)

Pignatti Elisa , Lachhab Asmaa , Casarini Livio , Wistuba Joachim , Schlatt Stefan , Carani Cesare , Simoni Manuela

Objective: Aromatase, the key enzyme involved in estrogen synthesis, is expressed in a variety of cells, including peripheral blood leukocytes (PBLs), and tissues. The systematic study of aromatase expression and activity in different tissues in the human and other primates, however, is difficult and still missing. Although is not really known, aromatase expression in PBLs could be used as parameter of aromatase expression/activity making PBLs a potential alternative for other...