Endocrine Abstracts

Refractory thyroid cancer is rare (4–5 cases/million population/year) and is responsible for most thyroid cancer related death. It includes patients with at least one tumor focus that does not concentrate radioiodine (RAI) or who progress within one year after RAI treatment despite uptake in all lesions.Treatment consists in levothyroxine to maintain a low TSH level and focal treatment modalities (surgery, EBRT, thermo-ablation). In case of multiple...

Refractory thyroid cancer is rare (4–5 cases/million population/year) and is responsible for most thyroid cancer related death. It includes patients with at least one tumor focus that does not concentrate radioiodine (RAI) or who progress within one year after RAI treatment despite uptake in all lesions.Treatment consists in levothyroxine to maintain a low TSH level and focal treatment modalities (surgery, EBRT, thermo-ablation). In case of multiple...

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Many (40%) patients with medullary thyroid carcinoma (MTC) are cured after initial surgery, others may survive for decades despite persistent disease, and few patients with advanced disease (estimated annual incidence in France: 50 cases) may require novel therapeutic modalities. An activating RET mutation is found in all hereditary MTCs and in half of sporadic MTCs, and is believed to be responsible for the neoplastic transformation of C-cells and for their development. Drugs...

Follow-up of thyroid cancer patients is aimed at controlling the adequacy of thyroid hormone treatment and at the early diagnosis of recurrent disease.Long term thyroxine treatment is given at suppressive doses only in the few patients with persistent or recurrent disease. When cure has been assessed, serum TSH should be maintained in the normal range (around 1 μU/ml).The absence of disease is first controlled by the to...

The quality of life of thyroid cancer patients is improved with the use of recombinant human TSH (rhTSH) that avoids hypothyroidism, provides an effective stimulation of any thyroid tissue and does not increase the global cost of treatment and follow-up. Several consensus and guidelines have recently delineated indications for using rhTSH.Post-operative radioiodine administration is not indicated for very low risk tumors (<1 cm, unifocal, intrathyroi...

Context: Peritoneal carcinomatosis (PC) is a rare site of distant metastasis in patients with adrenocortical cancer (ACC). One preliminary study suggests an increase risk of PC after adrenalectomy through laparoscopic approach of ACC.Objective: The objective of the study was to search for risk factors of PC including surgical approach. This was a retrospective cohort study conducted in an institutional practice.Patients: Sixty-four...

Germline activating mutations of the RET proto-oncogene are associated with inherited medullary thyroid cancer (MTC) and can be also detected in about 10% of apparently sporadic MTC cases. In the present study, 4 novel RET mutations, located in the extracellular domain (A510V, E511K and C531R) and in the intracellular juxtamembrane region (L666N), all identified by the genetic screening on sporadic MTC cases, are firstly reported and functionally characterized. RET Plasmids ca...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...

Interferon-α (IFN-α) has shown some activity in neuroendocrine tumors with disease stabilizations. Malignant pheochromocytoma and paraganglioma (MPPGLs) have a heterogeneous behavior with a slow progression rate, most of the time and a high frequency of bone metastases. Stabilizing disease and preventing skeletal-related events are two goals to achieve in the management of MPPGLs patients.This retrospective study evaluated a multimodal strategy...