Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp249 | Disturbances of Reproduction | ECE2019

Maternal 3rd trimester cortisol status was associated with offspring sex and PCOS status. Odense Child Cohort

Andersen Marianne , Jensen Richard , Schmedes Anne , Brandslund Ivan , Kyhl Henriette , Jensen Tina , Glintborg Dorte

Background: Maternal circulating cortisol and 24-h urinary free cortisol levels are up to three times higher in third trimester pregnant women compared to non-pregnant women. Maternal cortisol status could be associated with offspring sex, maternal PCOS and testosterone levels.Aims: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during 3rd trimester and to examine associations between maternal cortisol status,...

ea0063p309 | Reproductive Endocrinology 1 | ECE2019

Ano-genital distance in children born of mothers with polycystic ovary syndrome – Odense Child Cohort

Glintborg Dorte , Jensen Richard Christian , Schmedes Anne Vibeke , Brandslund Ivan , Kyhl Henriette Boye , Nielsen Tina Kold , Andersen Marianne Skovsager

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

ea0014p231 | (1) | ECE2007

Pioglitazone treatment significantly decreases 5-alpha reductase activity and improves metabolic risk factors in PCOS

Glintborg Dorte , Hermann Anne Pernille , Hagen Claus , Veldhuis Johannes , Schmedes Anne , Frystyk Jan , Flyvbjerg Allan , Andersen Marianne

Objective: To investigate the effect of pioglitazone on cortisol metabolism in PCOS.Design: Thirty insulin resistant PCOS patients were randomized to either 16 weeks of pioglitazone (30 mg/day) or placebo treatment. Before and after intervention, patients underwent 24 h 20 min.-integrated blood sampling for measurement of cortisol and 24 h excretion of cortisol, cortisone and steroid metabolites (cortisol, corticosteron, androgen, and 17-hydroxyprogester...