Searchable abstracts of presentations at key conferences in endocrinology

ea0014p100 | (1) | ECE2007

Inhibition of C17,20-lyase activity by new 17β-exo-heterocyclic androsterone derivatives

Szécsi Mihály , Tóth István , Wölfling János , Schneider Gyula , Julesz János

17α-Hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment of prostatic carcinoma, which is androgen-dependent in the majority of cases. Abiraterone and its analogues have been found strong inhibitors of P45017α suggesting that steroid de...