Searchable abstracts of presentations at key conferences in endocrinology

ea0007oc38 | Diabetes and metabolism | BES2004

Bacterial and yeast co-expression studies reveal hexose-6-phosphate dehydrogenase to be a crucial regulator of 11beta-hydroxysteroid dehydrogenase type 1 oxoreductase activity

Walker O , Schneider S , Edelstein M , Walker E , Arlt W , Stewart P

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has been implicated in the pathogenesis of human obesity and insulin resistance through 11-oxoreductase activation of cortisol (F) from cortisone (E) stimulating adipocyte differentiation and hepatic glucose output. In its purified state however, 11beta-HSD1 is a dehydrogenase inactivating F to E. In patients with cortisone reductase deficiency we recently identified two inactivating mutations, delta29bp and R453Q, withi...