Endocrine Abstracts

An 87 year old man was referred to our endocrine service from the medicine for the elderly team for investigation of suspected hypoglycaemia. He had several co-morbidities but did not have diabetes mellitus. There was a 6 month history of ‘funny episodes’ characterised by lethargy, profuse sweating and confusion. The symptoms resolved a few minutes after eating. One such episode occurred while attending his GP who arranged for blood to be drawn. The plasma glucose wa...

A previously well 27-year old female presented with atraumatic foot pain to the orthopaedic service and was identified to have a healing subacute metatarsal stress fracture in the right foot. In view of the unusual presentation, the patient was referred to the metabolic bone clinic for further evaluation.On initial evaluation the patient reported no prior skeletal, joint or dental problems. However at the time of review she reported pain in her right thi...

Pancreatic neuroendocrine tumours (NETs) are reported to show frequent mutations in chromatin remodelling genes, while pituitary NETS have alterations in histone modification. Histone modifications, and specifically acetylated residues on histone tails are recognised by members of the bromo and extra terminal (BET) protein family, via their bromodomains, causing alterations in the transcription of growth stimulating genes. BET bromodomain inhibitors have been demonstrated to s...