Searchable abstracts of presentations at key conferences in endocrinology

ea0055cb11 | Additional Cases | SFEEU2018

Spontaneous hypoglycaemia in an elderly man with suspected bladder cancer

Thurtell Craig , Schofield Chris

An 87 year old man was referred to our endocrine service from the medicine for the elderly team for investigation of suspected hypoglycaemia. He had several co-morbidities but did not have diabetes mellitus. There was a 6 month history of ‘funny episodes’ characterised by lethargy, profuse sweating and confusion. The symptoms resolved a few minutes after eating. One such episode occurred while attending his GP who arranged for blood to be drawn. The plasma glucose wa...

ea0044ep20 | (1) | SFEBES2016

Adult presentation of hypophosphatasia due to a novel compound heterozygous Tissue Nonspecific Alkaline Phosphatase (ALPL) mutation

Farrell Catriona , Strachan Judith , Sankar Sripada , McWilliam Catherine , Alipour Faz , Newey Paul , Schofield Chris

A previously well 27-year old female presented with atraumatic foot pain to the orthopaedic service and was identified to have a healing subacute metatarsal stress fracture in the right foot. In view of the unusual presentation, the patient was referred to the metabolic bone clinic for further evaluation.On initial evaluation the patient reported no prior skeletal, joint or dental problems. However at the time of review she reported pain in her right thi...

ea0034p174 | Neoplasia, cancer and late effects | SFEBES2014

Bromodomain inhibitors reduce proliferation and increase apoptosis of human neuroendocrine tumour cells

Lines Kate E , Stevenson Mark , Gaynor Katherine U , Newey Paul J , Piret Sian E , Lingard Hannah , Filippakopoulos Panagis , Muller Susanne , Grozinsky-Glasberg Simona , Grossman Ashley , Knapp Stefan , Schofield Chris , Bountra Chas , Thakker Rajesh V

Pancreatic neuroendocrine tumours (NETs) are reported to show frequent mutations in chromatin remodelling genes, while pituitary NETS have alterations in histone modification. Histone modifications, and specifically acetylated residues on histone tails are recognised by members of the bromo and extra terminal (BET) protein family, via their bromodomains, causing alterations in the transcription of growth stimulating genes. BET bromodomain inhibitors have been demonstrated to s...