Searchable abstracts of presentations at key conferences in endocrinology

ea0020p595 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone replacement therapy in adult onset growth hormone deficiency induces favorable long-term effects on quality of life, bone, body composition and lipids: a 55 month prospective study

Jorgensen Anders Palmstrom , Fougner Krisitan J , Schreiner Thomas , Bollerslev Jens

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

ea0063oc14.2 | Sex Hormones | ECE2019

The effect of testosterone therapy on serum oestradiol levels in transgender men

Defreyne Justine , Aers Xavier-Philippe , Daphne Fisher Alessandra , Schreiner Thomas , Den Heijer Martin , T'Sjoen Guy

Background: Testosterone therapy in transgender men (TM) is aimed at achieving serum testosterone levels in the male reference range. It remains unknown if serum oestradiol levels in TM should be evaluated and/or adjusted. Although reported serum oestradiol levels in TM are variable in the current literature, these values may be affected through two possible mechanisms: serum oestradiol levels may increase through aromatization of exogenous testosterone, while the effects of e...

ea0049ep1032 | Pituitary - Clinical | ECE2017

Does cyproterone acetate therapy contribute to the observed elevation in serum prolactin levels in trans women?

Defreyne Justine , Nota Nienke , Perreira Cecilia , Thomas Schreiner , Daphne Fisher Alessandra , Guy T'Sjoen

Objective: Hormonal treatment in trans women (MtF transgender persons) in Europe usually consists of estrogens and anti-androgens, e.g. cyproterone acetate (CPA). After initiation of cross-sex hormone therapy, an elevation in serum prolactin levels is frequently observed in trans women, which was previously attributed to estrogen agents. This analysis evaluates whether CPA contributes to the elevation of prolactin in trans women receiving cross-sex hormones.<p class="abste...

ea0041ep397 | Developmental endocrinology | ECE2016

Cross-sex hormone therapy affects body fat distribution in transgender persons

Klaver Maartje , Dekker Marieke , Schreiner Thomas , Fisher Alessandra , T'sjoen Guy , den Heijer Martin

Introduction: Fat distribution is an important secondary sex characteristic, which is generally peripherally or pear-shaped (gynoid) in females and centrally or apple-shaped (android) in males. Total body fat increases in male-to-females (MtFs) and decreases in female-to-males (FtMs) during cross-sex hormone therapy (CSHT), approaching body fat amounts of the desired sex. However, changes in android or gynoid fat distribution might be a better measure for masculinization and f...

ea0032p189 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Metabolic profile of transsexual persons on cross-sex hormonal therapy in a multi-center prospective intervention study

Van Caenegem Eva , Wierckx Katrien , Taes Youri , Kaufman Jean-Marc , Schreiner Thomas , T'Sjoen Guy

Introduction: Gender differences in insulin resistance, body composition and lipid profile are well known and related to sex steroid hormones. In this study, we examine the metabolic profile of transsexual persons undergoing drastic sex steroid changes, during the first year of hormonal therapy.Design: This research is part of a prospective intervention study conducted in several European gender teams (Ghent, Oslo, Amsterdam, and Florence).<p class="...

ea0022p509 | Growth factors | ECE2010

Two years of GH therapy improves body composition in adults with Prader–Willi Syndrome

Sode-Carlsen Rasmus , Farholt Stense , Rabben Kai Fr. , Bollerslev Jens , Schreiner Thomas , Christiansen Jens Sandahl , Hoybye Charlotte

Introduction: Prader–Willi syndrome (PWS) presents clinically with a multitude of findings, including abnormal body composition and partial GH deficiency. Until now three studies have reported beneficial effects upon body composition of GH treatment in adults with PWS. However, only one of these studies had the optimal randomised controlled design.Aim: The aim of this study was to confirm and substantiate the results from previous studies.<p cla...

ea0056p667 | Neuroendocrinology | ECE2018

Does gender affirming hormone therapy affect anger proneness in transgender persons?

Defreyne Justine , Elaut Els , Kreukels Baudewijntje , Heylens Gunter , Schreiner Thomas , Fisher Alessandra Daphne , Heijer Martin Den , T'Sjoen Guy

Introduction: Anger is an emotional state of feelings varying from mild irritation to intense rage, whereas aggression implies externalizing angry emotions through destructive/ punitive behavior towards other persons/objects. Although research on the relationship between testosterone and aggression is inconclusive, the WPATH SOC 7 guidelines have warned for an increase in aggression in transgender men (TM) taking testosterone treatment.Aims:<p class=...

ea0041oc11.1 | Bone &amp; Calcium Homeostasis | ECE2016

An increase of bone mineral density in male-to-female and female-to-male transgender persons after one year cross-sex hormonal treatment

Wiepjes Chantal , Vlot Mariska , Klaver Maartje , de Jongh Renate , Lips Paul , Heijboer Annemieke , Fisher Alessandra , Schreiner Thomas , T'Sjoen Guy , den Heijer Martin

Introduction: Estrogen has positive effects on bone mineral density (BMD), in particular in trabecular bone through inhibition of bone resorption. Testosterone increases bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transgender individuals can affect BMD. Therefore, the aim of this study is to investigate effects of CSHT on BMD during the first year of treatment in male-to-female (MtFs) and female-to-male (FtMs) transgender persons....

ea0070aep834 | Reproductive and Developmental Endocrinology | ECE2020

Vaginal bleeding and spotting in transgender men after initiation of testosterone therapy: A prospective cohort study (ENIGI)

Defreyne Justine , Vanwonterghem Yuran , Collet Sarah , Iwamoto Sean , Wiepjes Chantal , Fisher Alessandra , Schreiner Thomas , den Heijer Martin , T’Sjoen Guy

Background: Persistent vaginal bleeding can be psychologically stressful and incongruent with gender identity in transgender men (assigned female at birth with male gender identity). Previous studieshave cross-sectionally described amenorrhea in cohorts of transgender men on intramuscular or subcutaneous testosterone injections. It remains uncertain which testosterone preparations most effectively suppress vaginal bleeding and when amenorrhea occurs after testosterone initiati...