Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps2-15-08 | Hyperthyroidism | ETA2023

Extended pharmacometrics computer model utilizes heart rate to monitor thyroid function in adults with graves’ disease under carbimazole monotherapy

Steffens Britta , Koch Gilbert , Pfister Marc , Zuger Noemi , Bachmann Freya , Schropp Johannes , Johannes Betz Matthias , Szinnai Gabor

Objectives: GravesÂ’ disease (GD) is characterized by variable disease severity at diagnosis and variable disease activity during follow-up. Antithyroid drugs (ATD) such as carbimazole (CMZ), methimazole or propylthiouracil are the first-line treatment. Current guidelines recommend a range of ATD starting dose according to GD severity, followed by dose titration until euthyroidism is reached and a maintenance dose for a specific patient is established. As thyroid hormones ...