Searchable abstracts of presentations at key conferences in endocrinology

ea0014p9 | (1) | ECE2007

Regulation of GAGEC1, a cancer-testis associated antigen family member, by sex steroid hormones and TGF-beta: implications for prostatic disease

Sampson Natalie , Schuhfried Gerlinde , Plas Eugen , Berger Peter

Prostate homeostasis and function are regulated by complex interactions between the fibromuscular stroma and secretory epithelium via locally-derived and systemic paracrine- and autocrine-acting growth factors and sex steroid hormones. Stromal tissue remodelling due to alterations in transforming growth factor beta (TGF-β) and sex steroid hormone signalling are associated with benign prostatic hyperplasia (BPH) and prostate cancer (PCa), two of the most common proliferati...