Searchable abstracts of presentations at key conferences in endocrinology

ea0012p78 | Pituitary | SFE2006

Upregulation of Id1 and Id3 in response to BMP2 stimulation in LβT2 cells

Hanson PL , Sidhu KK , Schwarz N , Milligan T , Burrin JM

The pathogenesis of gonadotrophin secreting pituitary tumours (gonadotrophinomas) remains poorly understood. Bone morphogenetic proteins (BMPs) are important for the control of cell proliferation and differentiation and BMP2 is essential for commitment of undifferentiated pituitary cells to the gonadotroph cell lineage. In addition, BMPs have been implicated in tumourigenesis in a variety of tissues, associated with up-regulated expression of Id (Inhibitors of differentiation)...

ea0011p310 | Diabetes, metabolism and cardiovascular | ECE2006

Adrenomedullin increases the expression of CLR and RAMP2 in microvascular endothelial cells

Schwarz N , Sidhu K , Kapas S , Hinson JP

Adrenomedullin (AM) is a multifunctional peptide hormone which plays a significant role in vasodilation and angiogenesis, implicating it in hypertension as well as in carcinogenesis. AM exerts its effects via the Calcitonin Receptor-Like Receptor (CLR) complexed with either Receptor Activity Modifying Protein (RAMP) 2 or 3.The aim of the present study is to investigate the biological actions, functions and possible target genes of AM in immortalized Huma...

ea0008p38 | Diabetes, metabolism and cardiovascular | SFE2004


Schwarz N , Sidhu K , Kapas S , Hinson JP

Adrenomedullin (ADM) is a multifunctional peptide which plays a significant role in vasodilation, angiogenisis and septic shock. It exerts its effects via the calcitonin receptor-like receptor (CRLR) in combination with either receptor associated protein (RAMP) 2 or 3. However the regulation of the ADM receptors is still widely unknown (1). In the present study the effects of adrenomedullin on immortalized Human Microvascular Endothelial Cells (HMECs) was investigated. Endothe...