Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp107 | Diabetes therapy & complications 2 | ECE2017

Specific Oct1 gene variants are associated with changes in the risk of cardiovascular death in metformin users

Schweighofer Natascha , Genser Bernd , Marz Winfried , Kleber Marcus E , Pieber Thomas R , Obermayer-Pietsch Barbara

Aim: Increased cardiovascular incidents and a high risk for microvascular complications are associated with type 2 diabetes. Worldwide, metformin is the most commonly prescribed antidiabetic drug. Polymorphisms in the Oct1 gene can alter the function or activity of organic cation transporter 1 (Oct1), thus changing metformin efficacy (Oct1 acting as its main transporter) as well as influencing the actions of Oct1 physiological substrates. In the past, polymorphisms in...

ea0020p456 | Obesity and Metabolism | ECE2009

25-Hydroxyvitamin D is associated with insulin resistance, obesity, and serum lipids in polycystic ovary syndrome

Wehr Elisabeth , Pilz Stefan , Schweighofer Natascha , Giuliani Albrecht , Kopera Daisy , Pieber Thomas R , Obermayer-Pietsch Barbara

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting about 5-10% of women. PCOS is characterized by hyperandrogenism, ovulatory disturbances, and polycystic ovaries. Many women with PCOS present with insulin resistance and central obesity and are at an increased risk for developing diabetes and cardiovascular disorders. Vitamin D deficiency is an important pathogenetic factor in the development of type II diabetes. The aim of the study was to...

ea0073pep6.3 | Presented ePosters 6: Calcium and Bone | ECE2021

Characterization of sarcopenia via different DXA derived indices and associations with uc-dpMGP

Schweighofer Natascha , Strasser Moritz , Haudum Christoph , Schmidt Albrecht , Kolesnik Ewald , Pieber Thomas , Obermayer-Pietsch Barbara

Sarcopenia is a degenerative loss of skeletal muscle mass, quality, and strength. It increases the risk of falls and fractures, is associated with cardiac and respiratory disease and cognitive impairment and leads to mobility disorders. It decreases quality of life, leads to loss of independence, placement in long-term care and finally death. A variety of indices and parameters can be used to define sarcopenia. According to literature, matrix-GLA-protein (MGP) is associated wi...

ea0063p163 | Diabetes, Obesity and Metabolism 1 | ECE2019

Diabetes-, sex-, and BMI specific associations of genetic variants in PRRG1 with cardiovascular surrogates in a large cohort at CV risk

Schweighofer Natascha , Haudum Christoph W , Schmidt Albrecht , Kolesnik Ewald , Colantonio Caterina R , Pieske Burkert , Pieber Thomas R , Obermayer-Pietsch Barbara

The proline rich and Gla domain genes PRRG1-4 encode for short transmembrane proteins. PRRG proteins contain a Gla domain with glutamic acid residues which are gamma-carboxylated in a vitamin-K-depend manner. In a previous study, we were able to show a decrease in PRRG1 gene expression during intima thickening in atherosclerosis. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the vitamin-K-dependent protein PRRG1 with cardiovascular...

ea0041ep232 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Vascular calcification – Impact of PRRG1-4

Schweighofer Natascha , Aigelsreiter Ariane , Trummer Olivia , Kniepeiss Daniela , Wagner Doris , Stiegler Philipp , Pieber Thomas , Muller Helmut , Obermayer-Pietsch Barbara

Pathophysiological calcification in the vasculature favours cardio- and cerebrovascular diseases. In patients with chronic kidney disease vitamin K metabolites are associated with decreased vascular calcification.We investigated the expression of the vitamin K dependent proteins PRRG1-4 in vessels and bone to identify differences in expression pattern during atherosclerosis (AS) stages and compare the two tissue profiles.Gene expre...

ea0070ep190 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Matrix–GLA–protein and cardiovascular parameters: uc–dp MGP vs total MGP

Schweighofer Natascha , Strasser Moritz , Haudum Christoph , Schmidt Albrecht , Kolesnik Ewald , Pieske Burkert , Pieber Thomas , Obermayer–Pietsch Barbara

Matrix–GLA–protein ( MGP), independent of its posttranslational modification(s), has been associated with bone parameters and cardiovascular risk in patients with and without type 2 diabetes mellitus (T2DM). We investigated whether uncarboxylated, dephosphorylated MGP (uc–dp MGP), total MGP or both are associated with anthropometric and cardiovascular parameters such as carotid to femoral pulse wave velocity (PWV), intima–media thickness (IMT) and relat...

ea0020p471 | Obesity and Metabolism | ECE2009

Subcutaneous adipose tissue topography and metabolic disturbances in polycystic ovary syndrome

Wehr Elisabeth , Moller Reinhard , Horejsi Renate , Giuliani Albrecht , Kopera Daisy , Schweighofer Natascha , Pieber Thomas R , Obermayer-Pietsch Barbara

Objective: Central obesity plays a major role in the pathophysiology of polycystic ovary syndrome (PCOS). However, little information exists concerning the impact of subcutaneous adipose tissue (SAT) on metabolic disturbances in PCOS. The aim of this study was to investigate whether SAT topography influences insulin resistance, impaired glucose tolerance, and metabolic parameters in PCOS women.Design: Prospective case-control trial.<p class="abstext"...

ea0056gp63 | Cardiovascular | ECE2018

OCT1 gene variants are associated with cardiovascular characteristics in non-diabetic, prediabetic and diabetic patients

Schweighofer Natascha , Haudum Christoph , Schmidt Albrecht , Colantonio Caterina Raffaela , Mursic Ines , Pieber Thomas R , Obermayer-Pietsch Barbara

Type 2 diabetes (T2DM) patients are at high risk for vascular complications. Some of them have even a higher risk during metformin therapy, as we have recently shown by associations of polymorphisms in the Oct1 gene with a therapy-dependent increased risk of cardiovascular death. In this study, we investigated whether Oct1 gene variants were associated with cardiovascular characteristics such as pulse wave velocity (PWV), echocardiographic parameters and intima/media thickness...

ea0081ep368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is MGP an inflammatory marker?

Schweighofer Natascha , Colantonio Caterina , Haudum Christoph W , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , Pieber Thomas R , Verheyen Nicolas , Obermayer-Pietsch Barbara

Matrix-GLA-protein (MGP) was repeatedly associated with inflammation markers during the last decade. It is expressed in leucocytes and is a regulator of immune response. Due to posttranslational modification, there are 4 forms. The form responsible for immunomodulation is still unknown. Since the predicted active form - carboxylated, phosphorylated MGP - is not directly associated with immunomodulation, we aimed to investigate the association of dp-ucMGP (dephosphorylated, unc...

ea0063p1005 | Environment, Society and Governance | ECE2019

Genetic associations of vitamin D increase after supplementation

Trummer Olivia , Schweighofer Natascha , Haudum Christoph W , Trummer Christian , Lerchbaum Elisabeth , Pieber Thomas R , Colantonio Caterina , Kolesnik Ewald , Schmidt Albrecht , Pieske Burkert , Obermayer-Pietsch Barbara

Apart from the crucial effects of vitamin D on bone health, vitamin D deficiency has been associated with various chronic conditions such as metabolic or reproductive disturbances. The polycystic ovary syndrome (PCOS) represents the most common endocrine disorder among women of reproductive age. Women affected by PCOS frequently suffer from oligo- or anovulation as well as from obesity and insulin resistance. There is accumulating evidence showing an association of vitamin D s...