Searchable abstracts of presentations at key conferences in endocrinology

ea0021s8.4 | Role of the circadian clock in endocrinology | SFEBES2009

Human clock genes and the metabolic syndrome

Scott Eleanor

Life on earth is governed by the continuous 24-hour cycle of light and dark. Organisms have adapted to this environment with clear diurnal rhythms in their physiology and metabolism enabling them to anticipate predictable environmental fluctuations over the day and to optimise the timing of relevant biological processes to this cycle. It is of considerable interest that the normal diurnal variation in these processes is lost in the presence of insulin resistance, obesity and d...

ea0065p362 | Reproductive Endocrinology and Biology | SFEBES2019

Placental GLUT9 expression is associated with altered fetal growth in pregnancies complicated with GDM

Walsh Katy , Scott Eleanor , Forbes Karen

Gestational Diabetes Mellitus (GDM) is associated with adverse outcomes, including large-for-gestational age (LGA) babies who are are at greater risk of developing cardiovascular and metabolic diseases in adulthood. The mechanisms responsible for LGA are unclear but it is associated with altered placental development/function. Recent data also shows a link between temporal changes in maternal glucose and LGA; women with GDM that deliver appropriate for gestational age (AGA) in...

ea0077op3.2 | Reproductive and Neuroendocrinology | SFEBES2021

An ex-vivo human placental model demonstrates that temporal fluctuations in maternal glucose in gestational diabetes alter placental transcriptome networks associated vascular development and angiogenesis

Byford Abigail , Walsh Katy , Scott Eleanor , Forbes Karen

Aims: Women with gestational diabetes (GDM) who deliver large-for-gestational age (LGA) infants have subtle (1-1.5mM) differences in temporal maternal glucose control detectable by continuous glucose monitoring (CGM), compared to women who deliver appropriate-for-gestational-age (AGA) infants. It is unclear how these subtle changes cause LGA, but LGA has been linked to placental dysfunction. We aimed to develop an ex-vivo human placental model to mimic subtle differences in te...

ea0077p103 | Reproductive Endocrinology | SFEBES2021

Maternal fetuin-A (AHSG) serum levels are altered in pregnancies complicated by gestational diabetes and are associated with pathological fetal growth

Quilang Rachel , Gurung Dilasha , Scott Eleanor , Forbes Karen

Background: Gestational diabetes mellitus (GDM) is associated with increased rates of large-for-gestational-age (LGA) or small-for-gestational-age (SGA) infants. Currently, it is not possible to predict which women with GDM are at risk of delivering LGA or SGA infants. Fetuin-A, (α 2-Heremans Schmid glycoprotein; AHSG), a glycoprotein associated with insulin resistance is altered in GDM maternal serum. It is unclear if levels are related to altered fetal growth. This stud...

ea0077lb56 | Late Breaking | SFEBES2021

Placental levels of miR-1-3p and miR-133a-3p are decreased in pregnancies complicated gestational diabetes with large-for-gestational-age birth outcomes and may be influencing vascular smooth muscle differentiation

Kennedy Margeurite , Simpson Nigel , Scott Eleanor , Forbes Karen

Introduction: Gestational diabetes (GDM) affects 1 in 6 pregnancies globally, increasing babies’ risk of being born large-for-gestational-age (LGA). This can cause birth injuries and predisposes offspring to developing cardio-metabolic disease in adulthood. The cause of LGA in GDM is unclear, however GDM placentas have been shown to display abnormal morphology indicative of vascular network immaturity. MicroRNAs (miRNAs) are known regulators of vascular development, inclu...

ea0086oc3.4 | Reproductive and Neuroendocrinology | SFEBES2022

Maternally derived pancreatic extracellular vesicle miR-375 contributes to large-for-gestational-age infants in pregnancies complicated by gestational diabetes

Quilang Rachel , Byford Abigail , Scott Eleanor M , Forbes Karen

Pregnancies affected by GDM commonly result in large-for-gestational-age (LGA) infants, which have an increased risk of developing cardiometabolic complications. The mechanisms responsible are unclear but are associated with altered placental physiology. We have previously reported that miRNAs, including pancreatic specific miR-375, are altered in maternal serum extracellular vesicles (EVs) prior to the onset of LGA, and in term placenta. We assessed maternal pancreatic-derive...

ea0086p199 | Metabolism, Obesity and Diabetes | SFEBES2022

Temporal periods of mild hyperglycaemia in pregnancies complicated by gestational diabetes and LGA alter placental transcriptomic networks associated with vascularisation and M2 hofbauer cell polarisation

Byford Abigail , Walsh Katy , Holder Beth , Scott Eleanor , Forbes Karen

Background: Gestational diabetes (GDM) leads to an increased risk of delivering large-for-gestational-age infants (LGA), which has been linked to altered placental vascular development. Women with GDM who deliver LGA infants have temporal periods of mild hyperglycaemia, detectable by continuous glucose monitoring (CGM), compared to women who deliver appropriate-for-gestational-age infants (AGA). This study aimed to assess the impact of physiological periods and levels of hyper...

ea0086p269 | Reproductive Endocrinology | SFEBES2022

Metformin Exposure In-Utero Influences Placental Pathways Associated with Mitochondrial Activity

Owen Manon , Hugh Katie , Quilang Rachel , Scott Eleanor , Forbes Karen

Metformin is a first-line therapy for type-2 diabetes mellitus and gestational diabetes mellitus (GDM) which shows significant benefits for maternal health. However, offspring exposed to metformin in-utero have an increased risk of being born small for gestational age and developing cardiometabolic complications in adulthood. The mechanisms responsible are unknown. As fetal growth is dependent on optimal placental function, we assessed whether metformin exposure alter...

ea0028p185 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Association between rs1801260 of the circadian gene CLOCK and lipid and glucose metabolism in women with Polycystic Ovary Syndrome

Pernicova Ida , Akinci Baris , Prasai Madhu , Baxter Paul , Scott Eleanor

Introduction: The circadian clock controls numerous aspects of mammalian physiology across the 24 hour day, including lipid and glucose metabolism. Disruption of the core circadian gene CLOCK is associated with the development of obesity, diabetes and the metabolic syndrome in mice. Women with Polycystic Ovary Syndrome (PCOS) are at increased risk of developing diabetes, dyslipidemia and the metabolic syndrome. The aim of the present study was to investigate the relationship o...

ea0065oc6.3 | Reproductive Endocrinology and Biology | SFEBES2019

Investigating the impact of altered maternal extracellular vesicle miRNAs on placental function in women with gestational diabetes complicated by large for gestational age infants

Timms Kate , Cartland Sarah J , Ntostis Panagiotis , Saravanan Ponnusamy , Simpson Nigel , Scott Eleanor , Forbes Karen

Gestational diabetes mellitus (GDM) increases fetal morbidity/mortality, and is associated with elevated risks of offspring cardiometabolic disease. These risks are compounded in infants born large for gestational age (LGA) rather than appropriate size (AGA), a common complication of GDM associated with altered placental function. Circulating extracellular vesicle (EV)-associated miRNAs are internalised into the placenta and are emerging as key GDM mediators, with their role i...