Searchable abstracts of presentations at key conferences in endocrinology

ea0012p115 | Reproduction | SFE2006

Does metformin act via AMPK in the human ovary?

Pellatt L , Scott J , Rice S , Mason S

Metformin is commonly used to treat insulin resistance in women with polycystic ovary syndrome (PCOS) and also has direct effects on the ovary. The mechanism of this action is unknown, but could be via insulin-independent pathways, namely AMP activated protein kinase (AMPK). AMPK is an energy sensor, activated when ATP levels are depleted causing an inhibition of anabolic and an activation of catabolic pathways. We hypothesised that in the ovary, metformin acts via</...

ea0011p47 | Clinical case reports | ECE2006

Forced conservative management of a patient with pituitary tumour apoplexy and reduced conscious level

Advani A , James RA , Jenkins A , Parr JH , Scott J , Cooper R , Wahid ST

Historically, acute neurosurgical decompression has been considered treatment of choice for pituitary apoplexy with some studies advocating a conservative approach. We describe a patient, with reduced consciousness due to apoplexy of a gonadotroph adenoma, in whom there was spontaneous tumour shrinkage. A 68-year-old gentleman presented following a collapse with hypothermia, bradycardia and bitemporal hemianopia. Initial investigations showed low plasma sodium and glucose. Ove...

ea0016oc3.7 | Diabetes and obesity | ECE2008

Impact of metformin on gene expression, glucose uptake and lipolysis in adipocytes

Hadaschik Dirk , Andersson Ulrika , Kumaran Mande , Bochkina Natalia , Richardson Sylvia , Aitman Timothy J , Scott James , O'Rahilly Stephen , Siddle Kenneth

The biguanides metformin and phenformin enhance insulin sensitivity and improve glycaemic control in type 2 diabetes. Metformin is the most prescribed oral agent for type 2 diabetes but phenformin has been withdrawn because of its propensity to cause lactic acidosis. Metformin has a major effect in the liver where it reduces glucose output via AMPK activation. As the adipocyte is now considered to be a critical participant in whole-organism metabolic homeostasis we investigate...

ea0089c32 | Clinical – Surgery/Applied Pathology | NANETS2022

Surgical Management of G3 Gastroenteropancreatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis

Ziogas, MD, MPH Ioannis A. , T. Tasoudis, MD Panagiotis , C. Borbon, MD Luis , K. Sherman, MD, FACS Scott , J. Breheny, MS, PhD Patrick , Chandrasekharan, MBBS Chandrikha , S. Dillon, MD Joseph , M. Bellizzi, MD Andrew , R. Howe, MD, FACS James

Background: Grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are rare, aggressive tumors with poor prognosis. The WHO 2017 classification further subdivided G3 NENs into G3 neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). Current guidelines favor medical management in most of these patients, and the role of surgical management is not well-defined. We performed a systematic literature review and meta-analysis of surgical management vs ...