Searchable abstracts of presentations at key conferences in endocrinology

ea0007p63 | Diabetes, metabolism and cardiovascular | BES2004

Testosterone inhibits Ca2+ currents in A7r5 vascular smooth muscle cells, and in HEK293 cells stably expressing the alpha1C subunit of L-type Ca2+ channels (CaV1.2) and alpha1H T-type Ca2+ channels (CaV3.2)

Scragg J , Jones R , Channer K , Jones T , Peers C

Testosterone reduces myocardial ischaemia in men with coronary artery disease (CAD) and improves symptoms and exercise capacity in men with congestive heart failure (CHF), effects proposed to be due to testosterone-induced vasodilatation. Isolated vessel studies suggest this occurs via a calcium antagonistic action upon voltage-gated Ca2+ channels but this has yet to be investigated directly.We therefore employed patch clamp methodology to stu...