Searchable abstracts of presentations at key conferences in endocrinology

ea0010p95 | Thyroid | SFE2005

Thyroid dysfunction in HIV

Qureshi A , Panahloo A , Seal L

A 54 yr old man presented with a six-month history of palpitations, sweating and weight loss. He had a past history of hypertension, type II diabetes, asthma and was HIV-1 seropositive since 14 yrs and was taking potent anti-retroviral therapy: Nevirapine 200 mg bd; Kaletra 3 capsules bd; and didanosine ec 400 mg od.Investigations confirmed Graves thyrotoxicosis (fT4 72.1 pmol/l; TSH <0.01 mU/l; and TSH receptor antibody positive). He was initially t...

ea0008dp10 | Diabetes, metabolism and cardiovascular | SFE2004

All men attending diabetes clinics should have serum testosterone measure as it correlates with HDL and sexual dysfunction

Weller A , Seal L

Method: Male diabetic patients attending erectile dysfunction clinic) and general diabetes clinic were studied . Plasma androgen levels were obtained and erectile function assessed using the International Index of Erectile Function (IIEF). Results:Low testosterone showed correlated with increasing age and BMI.Low testosterone correlated with HDL.HbA1c showed positive correlation with intercourse satisfaction....

ea0019p74 | Clinical practice/governance and case reports | SFEBES2009

Thiazolindinediones are useful in achieving female type fat distribution in male to female transsexuals

Malik I , Barrett J , Seal L

A 45-year-old male to female transsexual presented with poor female fat distribution. She had been treated with oestrogen for 13 years, initially as ethinyl oestradiol to a maximum dose of 150 ug/day, presently taking 100 mcg with GNRH analogue. On this regimen she had B cup breast development but underwent breast augmentation surgery and still suffered from low self-esteem. She was dissatisfied with her body image because she perceived a male body fat distribution. Her initia...

ea0008p9 | Clinical case reports | SFE2004

Conservative management of a visual field defect

Ahmed TJ , Simpson-Davis S , Seal L

Mrs. P.A., a 75 year old lady, presented to Accident and Emergency with a severe persistent headache of 3 days duration. She was disorientated and drowsy. She has a history of type 2 diabetes, hypertension, hypercholesterolaemia, depression and hypothyroidism. She was a smoker of 20 a day and consumed no alcohol. Her Glasgow Coma Scale was 13/15, her examination was normal. An initial CT head showed a pituitary tumour with haemorrhage. Tests showed an FSH of 14.1 IU/L, LH 2.9 ...

ea0019p72 | Clinical practice/governance and case reports | SFEBES2009

Late onset congenital adrenal hyperplasia masquerading as subclinical Cushing’s syndrome

Loh V , Krishnan B , Prentice M , Panahloo A , Seal L

A 54-year-old Afro–Carribean woman developed worsening obesity, hypertension, and proximal muscle weakness. Clinical examination revealed cushingoid facies, truncal obesity (BMI 34.8), abdominal striae and a BP of 150/90, Ferriman–Gallway score 12.Investigations:- FBG 10.7 mmol/l, 24 urine cortisols 147 mmol/l, 207 mmol/l (NR 25–280 nmol/24 h), normal short synacthen test (cortisol 471 rising to 1002 nmol/l). Subsequent testing revealed a ...

ea0019p297 | Reproduction | SFEBES2009

Total testosterone correlates better than free testosterone with metabolic disturbance in diabetes

Loh V , Krishnan B , Sugihara C , Panahloo A , Seal L

There is a known correlation between dyslipidaemia and hypogonadism in diabetes. In non-diabetic men, calculated free testosterone correlates better than total testosterone with the elements of the metabolic syndrome. The aim of this study is to investigate if this was also true in diabetic men.Methods: This is a retrospective observational study. We analyzed biochemical parameters from 140 sequential male diabetic patients who attended the diabetic erec...

ea0011p109 | Clinical case reports | ECE2006

A complex case of pregnancy and pegvisamont treated acromegaly

Qureshi AI , Ramanathan G , Walton A , Seal L , Bano G , Manyonda I , Panahloo A

A 29-year-old woman with polycystic ovary syndrome was diagnosed with acromegaly having presented with a two year history of secondary amenorrhea, a change in physical appearance and sweating. The diagnosis was confirmed with an oral glucose tolerance test that also demonstrated she had impaired glucose tolerance. Radiological imaging demonstrated a 2.2 cm pituitary tumor that was compressing the optic chiasm and a bi-temporal visual field defect was confirmed on Goldman field...

ea0006p8 | Clinical case reports | SFE2003

Tall or thin

Shariff M , Dhillo W , Tunariu N , Todd J , Seal L , Meeran K

A 19 year old university student who participated in athletics presented with secondary amenorrhoea. Examination revealed no features of endocrine disease. A pituitary profile showed normal serum thyroid function and prolactin, but undetectable LH, FSH, and oestradiol. Random serum GH level was detectable (9 milli units per litre), but IGF1 level was low, 72 (190-530 micrograms per litre). An OGTT demonstrated a paradoxical rise in her GH levels (3.5, 2.2, 38, 33, 20; mean GH ...

ea0003p206 | Neuroendocrinology | BES2002

Prolactin releasing peptide does not have a significant role in the control of growth hormone secretion either in vitro or in vivo in freely moving male rats

Seal L , Small C , Wren A , Dhillo W , Ghatei M , Bloom S

Prolactin releasing peptide (PrRP) is reported to decrease plasma growth hormone (GH) levels in the rat but increase GH release from human pituitary cells. A barbiturate anaesthetised model was used in the rat studies (where basal plasma growth hormone is elevated) and in humans the GH stimulatory effects were of a small magnitude and seen only in foetal or tumourous pituitary cells. Our studies have examined the role of PrRP in freely moving male rats without the influence of...

ea0002oc11 | Neuroendocrinology | SFE2001

Systemic and Hypothalamic Actions of Ghrelin in Regulation of Food Intake, Body Weight and Pituitary Function

Wren A , Small C , Abbott C , Seal L , Ghatei M , Bloom S

Ghrelin, an endogenous growth hormone secretagogue receptor agonist, increases food intake, growth hormone (GH) and adrenocorticotrophic hormone (ACTH) following intracerebroventricular (ICV) and systemic administration. We now show that low dose intraperitoneal (ip) ghrelin (1nmol) stimulates feeding and results in a plasma ghrelin concentration not significantly different to 24-hour fasting levels. Following injection into 8 hypothalamic nuclei, ghrelin (30pmol) potently sti...