ea0070aep849 | Reproductive and Developmental Endocrinology | ECE2020
Lazzaretti Clara
, Secco Valentina
, Paradiso Elia
, Sperduti Samantha
, Rutz Claudia
, Kreuchwig Annika
, Krause Gerd
, Simoni Manuela
, Casarini Livio
The human luteinizing hormone (LH)/choriogonadotropin (hCG) receptor (LHCGR) discriminates its two hormone ligands. LHCGR differs to the murine receptor (Lhr) in aminoacid residues potentially involved in qualitative discerning of LH and hCG, the latter absent in rodents. We aim to identify LHCGR residues involved in hCG/LH discrimination, indicating evolutionary determinants of human LH/hCG endocrine system. After comparing the LHCGR and Lhr sequences, we developed eight ...