Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep28 | Adrenal cortex (to include Cushing's) | ECE2016

Adenoma size could be an important predictor of Subclinical Cushing’s Syndrome

Yener Serkan , Baris Mustafa , Demirpence Mustafa , Ozisik Secil , Cavdar Umit , Demir Omer , Secil Mustafa , Comlekci Abdurrahman

Subclinical Cushing’s syndrome (SCs) is used to refer to an adrenal incidentaloma with subtle autonomous cortisol secretion and without typical signs and symptoms of hypercortisolism. Diagnostic criteria are uncertain and arbitrary. In this study we aimed to investigate the power of adenoma size as an independent predictor of SCs.Dokuz Eylul University Adrenal Tumours Study Group database includes 596 patients by January 2016. Briefly, there are 332...

ea0037ep62 | Adrenal cortex | ECE2015

Prospective evaluation of cardiovascular risk in subclinical Cushing's syndrome

Yener Serkan , Cekdemir Yasin , Baris Mustafa , Demirpence Mustafa , Demir Tevfik , Secil Mustafa

Introduction: Natural history of adrenal incidentalomas has not been totally understood. Current data from subjects with adrenal incidentalomas demonstrated an increased rate of metabolic disturbances and cardiovascular risk. It has been shown that subjects with subclinical cortisol excess were more susceptible to diabetes, hypertension, and obesity. However, there is no data regarding prospective cardiovascular risk evaluation in subjects with subclinical Cushing’s syndr...

ea0032p629 | Growth hormome IGF axis – basic | ECE2013

Determinants of carotid intima media thickness in acromegaly patients

Yilmaz Merve , Gedik Arzu , Basaloglu Can , Cimrin Dilek , Ellidokuz Hulya , Secil Mustafa , Comlekci Abdurrahman

Introduction: Acromegaly is a rare disease characterized by GH and IGF1 hypersecretion and increased cardiovascular mortality. Ultrasonographic measurement of carotid intima media thickness (CIMT) gives substantial information about early atherosclerosis. We aimed to evaluate CIMT and its determinants in a group of acromegaly patient.Patients and methods: Forty-four acromegaly patient and 43 age, sex and body mass index (BMI) matched healthy controls wer...

ea0020p32 | Adrenal | ECE2009

Is adrenal adenoma associated with the development of non-alcoholic fatty liver disease?

Yener Serkan , Ertilav Senem , Secil Mustafa , Akinci Baris , Demir Tevfik , Bayraktar Firat , Yesil Sena

It has been previously shown that adrenal adenomas are associated with a variety of metabolic disturbances like glucose intolerance and obesity. The aim of this study is to demonstrate the risk of non-alcoholic fatty liver disease development in subjects with adrenal incidentalomas.Among 302 subjects referred between 2001 and 2008 for the evaluation of incidentally discovered adrenal mass, 150 subjects with appropriate data were included. Computed tomogr...

ea0020p41 | Adrenal | ECE2009

Prospective evaluation of metabolic and anthropometric parameters in non-functioning adrenal adenomas

Yener Serkan , Ertilav Senem , Comlekci Abdurrahman , Secil Mustafa , Akinci Baris , Demir Tevfik , Yesil Sena

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...

ea0020p53 | Adrenal | ECE2009

Prospective evaluation of tumour size and hormone secretion in adrenal incidentalomas

Yener Serkan , Ertilav Senem , Secil Mustafa , Akinci Baris , Demir Tevfik , Comlekci Abdurrahman , Yesil Sena

Increased use and improved technology of imaging procedures have led to increased recognition of adrenal incidentalomas. The aim of this study is to evaluate the natural course of benign adrenal tumours in terms of tumour growth and hormone secretion.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2...

ea0016p699 | Thyroid | ECE2008

Thymic hyperplasia presenting as a neck mass in Graves' disease

Yener Serkan , Secil Mustafa , Kocdor Mehmet Ali , Ozdogan Ozhan , Comlekci Abdurrahman , Yesil Sena

Introduction: Thymic hyperplasia is a rare manifestation of Graves disease. In this report, we describe a female with Graves’ disease and a neck mass that was associated with thymic hyperplasia.Case report: A 28-year-old woman was referred to our division for the evaluation of palpitations. Thyroid function tests were associated with thyrotoxicosis. Thyroid receptor antibody (TRAb) was found to be 22.3 U/l (positive: >14 U/l). Sonography showed ...

ea0014p289 | (1) | ECE2007

The effects of subclinical hypothyroidism and replacement therapy on paraoxonase-1 (PON-1) and common carotis intima media thickness

Kebapcilar Levent , Comlekci Abdurrahman , Tuncel Pinar , Solak Ahmet , Secil Mustafa , Gencel Omur , Yesil Sena

The mechanism of atherosclerosis in patients with subclinical hypothyroidism (sHT), which has been partly attributed to lipid abnormalities, is still controversial. There is substantial evidence that ox-LDL plays an important role during the atherosclerosis process and paraoxonase-1 (PON-1) significantly inhibits generation of lipid peroxidation and thus plays a role in against atherosclerosis. The aim of the study was evaluate qualitative changes in lipoprotein metabolism, hs...

ea0022p807 | Thyroid | ECE2010

Cytologic results of thyroid fine needle aspiration biopsy from geriatric patients; A single centre experience

Yalcin Mehmet Muhittin , Yener Serkan , Akinci Baris , Yesil Sena , Bayraktar Firat , Comlekci Abdurrahman , Secil Mustafa , Canda Tulay

Fine needle aspiration biopsy is the cornerstone for cytologic evaluation of thyroid nodules. Thyroid nodule prevelance increases with age, however there is no cytologic study exclusively from geriatric patients.We examined the thyroid fine needle biopsy records taken from patients age 65 years or older between January 2006 and June 2009 at Dokuz Eylul University Hospital; and reviewed the cytological results of this group.We analy...

ea0020p102 | Thyroid | ECE2009

Levothyroxine suppression treatment for benign thyroid nodules alters coagulation

Demir Tevfik , Akinci Baris , Comlekci Abdurrahman , Karaoglu Oguzhan , Ozcan Mehmet Ali , Yener Serkan , Yuksel Faize , Secil Mustafa , Yesil Sena

Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.Design: Prospective case-control study.Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.Meas...