Searchable abstracts of presentations at key conferences in endocrinology

ea0011s15 | The endocrinology of psychiatric disease | ECE2006

Glucocorticoids, enzymes and memory impairments with ageing

Seckl JR

Chronic elevation of plasma glucocorticoids adversely affects cognitive processes and the structural and functional integrity of the hippocampus. Crucially, inter-individual differences in memory with ageing directly associate with blood glucocorticoid levels in rodents and humans; indeed higher plasma corticosterone in mid-life in rodents predict subsequent memory impairments. However, although keeping glucocorticoid levels low by adrenalectomy in adult life prevents the emer...

ea0019p306 | Steroids | SFEBES2009

Prenatal dexamethasone programmes renal 11β-hydroxysteroid dehydrogenase type 2 expression

Tang JI , Seckl JR , Nyirenda MJ

Numerous epidemiological studies worldwide have shown a strong association between low birth weight and an increased risk of developing cardiometabolic disease, including hypertension. Excessive fetal exposure to glucocorticoids has been hypothesised to mediate this relationship. Here, we have used an established rodent model – in which dexamethasone, a synthetic glucocorticoid that readily crosses the placenta, is administered to pregnant Wistar rats during the last trim...

ea0011oc39 | Neuroendocrinology and neoplasia | ECE2006

11 beta hydroxysteroid dehydrogense modulation of HPA function – importance of genetic background

Carter RN , Tworowska U , Seckl JR , Holmes MC

Various psychiatric conditions have been associated with stress and alterations in hypothalamic-pituitary-adrenal (HPA) activity. Yet while stress is a general phenomenon, illness is only seen in a proportion of individuals, suggesting genetic modifiers of ability to cope with stress. 11-beta hydroxysteroid dehydrogenase type 1 (HSD1) regenerates corticosterone from inert 11-dehydrocorticosterone, amplifying the levels of glucocorticoids and is expressed in the brain. To deter...

ea0011oc9 | Steroids and reproductive endocrinology | ECE2006

11β-HSD1: anti-inflammatory mechanism in acute and chronic inflammation?

Coutinho AE , Gray M , Sawatzky DA , Brownstein D , Mullins J , Seckl JR , Savill JS , Chapman KE

Although the anti-inflammatory effects of exogenous glucocorticoids (GC) upon inflammation are well recognized, the contribution of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an amplifier of GC action in vivo, in modulating endogenous GC action during inflammation is unknown. Mouse models of arthritis and lung inflammation were used to explore the role of 11β-HSD1 in acute and chronic inflammation. Arthritis was induced in 11β-HSD1−/&#...

ea0011oc27 | Diabetes and metabolism | ECE2006

A selective increase in adipose 11β-HSD1 expression in corticosterone-treated Pomc null mice is associated with development of metabolic syndrome

Michailidou ZM , Coll APC , Morton NMM , Kenyon CJ , O’Rahilly S , Seckl JR , Chapman KE

Inactivating mutations of the POMC gene in humans and mice result in a complex phenotype of hyperphagia, obesity and glucocorticoid (GC) deficiency, but without many features of metabolic syndrome. We have previously shown that replacement of GC in Pomc−/− mice exacerbates their hyperphagia, increases fat mass and elevates plasma leptin and insulin. We have now examined key determinants of glucocorticoid action, including glucocorticoid receptor (...

ea0011p385 | Diabetes, metabolism and cardiovascular | ECE2006

Dietary regulation of peripheral glucocorticoid action: comparison of saturated and unsaturated fats

Man TY , Ramage L , Gokcel A , Michailidou Z , Kenyon CJ , Chapman K , Seckl JR , Morton NM

Obesity/Metabolic syndrome (insulin resistance, hypertension, cardiovascular disease) has reached epidemic levels in western societies. Aberrantly elevated glucocorticoid amplification by intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) within adipose tissue might explain the striking similarities between idiopathic obesity/metabolic syndrome and Cushing’s syndrome, causes by plasma GC excess. A major contributor to obesity/metabol...