Searchable abstracts of presentations at key conferences in endocrinology

ea0029gh1 | The Geoffrey Harris Prize Lecture | ICEECE2012

Glucocorticoid metabolism and the brain, from fetal programming to senescence

Seckl Jonathan R

Chronic elevation of glucocorticoids adversely impacts on cognition and the integrity of hippocampal cells. Moreover, inter-individual differences in memory with ageing correlate directly with blood glucocorticoid levels in rodents and humans. Beyond plasma steroid levels, glucocorticoid action on target tissues is determined by the density of nuclear receptors and by intracellular metabolism by 11β-hydroxysteroid dehydrogenases (11β-HSDs) which catalyse interconvers...

ea0031p181 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The role of hepatic 11β-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

Manwani Kajal , Man Tak Y , Kenyon Christopher J , Andrew Ruth , Chapman Karen E , Seckl Jonathan R

11β-Hydroxysteroid dehydrogenase type one (11β-HSD1) converts inert glucocorticoids to active forms, amplifying intracellular glucocorticoid action. 11β-HSD1 also catalyses the reduction of seven-ketocholesterol (7KC) to 7β-hydroxycholesterol (7βHC). 7KC may inhibit cholesterol biosynthesis (Brown et al. 2002). Alteration of cholesterol homeostasis is a major atherosclerotic risk factor. 11β-HSD1 deficiency/inhibition is atheroprotective ...

ea0021oc3.2 | Young Endocrinologists prize session | SFEBES2009

β-Cell specific overexpression of 11β-hydroxysteroid dehydrogenase type 1 reverses high fat diet-induced β-cell failure

Turban-Rajaonah Sophie , Liu Xiaoxia , Ramage Lynne , Mullins John J , Seckl Jonathan R , Morton Nicholas M

Insulin-resistant diabetes is characterised by progressive pancreatic β-cell dysfunction. Elevated pancreatic islet activity of the intracellular glucocorticoid amplifying enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) was hypothesized to drive this process in genetically obese rodents. To determine the direct effects of elevated 11β-HSD1 on β-cell function in diabetes in vivo we created a transgenic model overexpressing 11β-HSD1...

ea0025oc1.5 | Young Endocrinologists prize session | SFEBES2011

Atheroprotection by 11β-HSD1 deficiency in ApoE−/− mice: role of both glucocorticoid and 7-oxysterol factors

Mitic Tijana , Hadoke Patrick W F , Chuaiphichai Surawee , Man Taq Y , Miller Eileen , Andrew Ruth , Walker Brian R , Chapman Karen E , Seckl Jonathan R

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoids thus amplifying their intracellular actions. 11β-HSD1 deficiency or inhibition, which improve metabolic syndrome and attenuate atherosclerosis in vulnerable rodent strains, is a target for drug development. However, 11β-HSD1 also converts 7-ketocholesterol (7KC) (which accumulates in fatty tissues), to the potentially more atherogenic, 7β-hydroxycholesterol. Whether a...

ea0019oc9 | Neuroendocrine and Steroids | SFEBES2009

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

Yang Fu , Duffin Rodger , Brownstein David G , Coutinho Agnes , Rossi Adriano G , Savill John S , Seckl Jonathan R , Chapman Karen E

Glucocorticoids are potent anti-inflammatory agents. Endogenous glucocorticoid action is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) which interconverts active (cortisol, corticosterone) and intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone). 11β-HSD type 1 regenerates active glucocorticoids. 11β-HSD 1 highly expressed in the lung but its role is little explored.Immunohistochemical staining of mouse ...