Searchable abstracts of presentations at key conferences in endocrinology

ea0028p338 | Thyroid | SFEBES2012

PBF interacts with cortactin and thyroglobulin in thyroid cells

Sharma Neil , Smith Vicki , Seed Rob , Read Martin , Lewy Gregory , Ryan Gavin , Fong Jim , Kwan Perkin , Watkinson John , Martin Ashley , Boelaert Kristien , Franklyn Jayne , McCabe Chris

PBF is a proto-oncogene implicated in the aetiology of thyroid cancer. Recently, we have shown that PBF binds NIS, MCT8 and p53, but the full spectrum of its interactions and physiological role within the thyroid remain unknown. Previously, we reported a shortlist of potential binding partners elucidated from K1 and TPC1 papillary thyroid carcinoma cells using tandem mass spectrometry (MS/MS, n=4). Here we present validation and characterisation of 2 of these proteins; ...